A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large-scale sequencing efforts. Using genome-scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and confirmed...

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Detalles Bibliográficos
Autores principales: Vizeacoumar, Franco J, Arnold, Roland, Vizeacoumar, Frederick S, Chandrashekhar, Megha, Buzina, Alla, Young, Jordan T F, Kwan, Julian H M, Sayad, Azin, Mero, Patricia, Lawo, Steffen, Tanaka, Hiromasa, Brown, Kevin R, Baryshnikova, Anastasia, Mak, Anthony B, Fedyshyn, Yaroslav, Wang, Yadong, Brito, Glauber C, Kasimer, Dahlia, Makhnevych, Taras, Ketela, Troy, Datti, Alessandro, Babu, Mohan, Emili, Andrew, Pelletier, Laurence, Wrana, Jeff, Wainberg, Zev, Kim, Philip M, Rottapel, Robert, O’Brien, Catherine A, Andrews, Brenda, Boone, Charles, Moffat, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817404/
https://www.ncbi.nlm.nih.gov/pubmed/24104479
http://dx.doi.org/10.1038/msb.2013.54

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