Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

Regioselective conjugate 1,4-trifluoromethylation of α,β-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl–aryl–enones and aryl–alkyl–enone...

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Detalles Bibliográficos
Autores principales: Okusu, Satoshi, Sugita, Yutaka, Tokunaga, Etsuko, Shibata, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817478/
https://www.ncbi.nlm.nih.gov/pubmed/24204432
http://dx.doi.org/10.3762/bjoc.9.257
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author Okusu, Satoshi
Sugita, Yutaka
Tokunaga, Etsuko
Shibata, Norio
author_facet Okusu, Satoshi
Sugita, Yutaka
Tokunaga, Etsuko
Shibata, Norio
author_sort Okusu, Satoshi
collection PubMed
description Regioselective conjugate 1,4-trifluoromethylation of α,β-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl–aryl–enones and aryl–alkyl–enones were converted into β-trifluoromethylated ketones in low to moderate yields.
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spelling pubmed-38174782013-11-07 Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system Okusu, Satoshi Sugita, Yutaka Tokunaga, Etsuko Shibata, Norio Beilstein J Org Chem Letter Regioselective conjugate 1,4-trifluoromethylation of α,β-unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl–aryl–enones and aryl–alkyl–enones were converted into β-trifluoromethylated ketones in low to moderate yields. Beilstein-Institut 2013-10-23 /pmc/articles/PMC3817478/ /pubmed/24204432 http://dx.doi.org/10.3762/bjoc.9.257 Text en Copyright © 2013, Okusu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Okusu, Satoshi
Sugita, Yutaka
Tokunaga, Etsuko
Shibata, Norio
Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title_full Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title_fullStr Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title_full_unstemmed Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title_short Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
title_sort regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a s-(trifluoromethyl)diphenylsulfonium salts/copper system
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817478/
https://www.ncbi.nlm.nih.gov/pubmed/24204432
http://dx.doi.org/10.3762/bjoc.9.257
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