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The chemistry of isoindole natural products
This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids fr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817534/ https://www.ncbi.nlm.nih.gov/pubmed/24204418 http://dx.doi.org/10.3762/bjoc.9.243 |
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author | Speck, Klaus Magauer, Thomas |
author_facet | Speck, Klaus Magauer, Thomas |
author_sort | Speck, Klaus |
collection | PubMed |
description | This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples. Within different congeners, we have selected a few members and discussed the synthetic routes in more detail. The putative biosynthetic pathways of the presented isoindole alkaloids are described as well. |
format | Online Article Text |
id | pubmed-3817534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-38175342013-11-07 The chemistry of isoindole natural products Speck, Klaus Magauer, Thomas Beilstein J Org Chem Review This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloids. Concerning their biological activity, molecular structure and synthesis, we have limited this review to the most inspiring examples. Within different congeners, we have selected a few members and discussed the synthetic routes in more detail. The putative biosynthetic pathways of the presented isoindole alkaloids are described as well. Beilstein-Institut 2013-10-10 /pmc/articles/PMC3817534/ /pubmed/24204418 http://dx.doi.org/10.3762/bjoc.9.243 Text en Copyright © 2013, Speck and Magauer https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Review Speck, Klaus Magauer, Thomas The chemistry of isoindole natural products |
title | The chemistry of isoindole natural products |
title_full | The chemistry of isoindole natural products |
title_fullStr | The chemistry of isoindole natural products |
title_full_unstemmed | The chemistry of isoindole natural products |
title_short | The chemistry of isoindole natural products |
title_sort | chemistry of isoindole natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817534/ https://www.ncbi.nlm.nih.gov/pubmed/24204418 http://dx.doi.org/10.3762/bjoc.9.243 |
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