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Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease

The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of...

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Autores principales: Falcone, Colomba, Bozzini, Sara, Guasti, Luigina, D'Angelo, Angela, Capettini, Anna Clizia, Paganini, Edoardo Maria, Falcone, Rossana, Moia, Roberto, Gazzaruso, Carmine, Pelissero, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817642/
https://www.ncbi.nlm.nih.gov/pubmed/24228009
http://dx.doi.org/10.1155/2013/584504
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author Falcone, Colomba
Bozzini, Sara
Guasti, Luigina
D'Angelo, Angela
Capettini, Anna Clizia
Paganini, Edoardo Maria
Falcone, Rossana
Moia, Roberto
Gazzaruso, Carmine
Pelissero, Gabriele
author_facet Falcone, Colomba
Bozzini, Sara
Guasti, Luigina
D'Angelo, Angela
Capettini, Anna Clizia
Paganini, Edoardo Maria
Falcone, Rossana
Moia, Roberto
Gazzaruso, Carmine
Pelissero, Gabriele
author_sort Falcone, Colomba
collection PubMed
description The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. Clinical and laboratory parameters including the ankle brachial index (ABI) and sRAGE (enzyme-linked immunosorbent assay kit) were investigated in 544 patients with angiographically documented CAD and 328 control subjects. 213/554 CAD patients (39%) showed an ABI <0.9 associated with typical symptoms (group CAD + PAD), whereas 331 patients were free from PAD. The concentration of plasma sRAGE was significantly lower (P < 0.0001) in CAD population, with and without PAD, than in control subjects. Among CAD patients, those with PAD showed lower levels of sRAGE. The distribution of the three groups (CAD, CAD + PAD, and controls) according to sRAGE tertiles showed that lower levels were more frequent in patients with CAD and CAD + PAD, whereas higher levels were more frequently found in controls. CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE.
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spelling pubmed-38176422013-11-13 Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease Falcone, Colomba Bozzini, Sara Guasti, Luigina D'Angelo, Angela Capettini, Anna Clizia Paganini, Edoardo Maria Falcone, Rossana Moia, Roberto Gazzaruso, Carmine Pelissero, Gabriele ScientificWorldJournal Research Article The objective of the present study was define in a relatively large patient population with coronary artery disease (CAD) whether the concomitant presence of peripheral artery disease (PAD), which is known to convey additional cardiovascular risk, was associated with different circulating levels of sRAGE with respect to CAD alone and control subjects. Clinical and laboratory parameters including the ankle brachial index (ABI) and sRAGE (enzyme-linked immunosorbent assay kit) were investigated in 544 patients with angiographically documented CAD and 328 control subjects. 213/554 CAD patients (39%) showed an ABI <0.9 associated with typical symptoms (group CAD + PAD), whereas 331 patients were free from PAD. The concentration of plasma sRAGE was significantly lower (P < 0.0001) in CAD population, with and without PAD, than in control subjects. Among CAD patients, those with PAD showed lower levels of sRAGE. The distribution of the three groups (CAD, CAD + PAD, and controls) according to sRAGE tertiles showed that lower levels were more frequent in patients with CAD and CAD + PAD, whereas higher levels were more frequently found in controls. CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE. Hindawi Publishing Corporation 2013-10-09 /pmc/articles/PMC3817642/ /pubmed/24228009 http://dx.doi.org/10.1155/2013/584504 Text en Copyright © 2013 Colomba Falcone et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Falcone, Colomba
Bozzini, Sara
Guasti, Luigina
D'Angelo, Angela
Capettini, Anna Clizia
Paganini, Edoardo Maria
Falcone, Rossana
Moia, Roberto
Gazzaruso, Carmine
Pelissero, Gabriele
Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title_full Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title_fullStr Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title_full_unstemmed Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title_short Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
title_sort soluble rage plasma levels in patients with coronary artery disease and peripheral artery disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817642/
https://www.ncbi.nlm.nih.gov/pubmed/24228009
http://dx.doi.org/10.1155/2013/584504
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