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Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines

Transitional metals and metal compounds have been used in versatile platforms for biomedical applications and therapeutic intervention. Severe side effects of anticancer drugs produce an urgent urge to develop new classes of anticancer agents with great potency as well as selectivity. In this backgr...

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Autores principales: Dash, Sandeep Kumar, Chattopadhyay, Sourav, Ghosh, Totan, Tripathy, Satyajit, Das, Sabyasachi, Das, Debasis, Roy, Somenath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817708/
https://www.ncbi.nlm.nih.gov/pubmed/24223312
http://dx.doi.org/10.1155/2013/709269
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author Dash, Sandeep Kumar
Chattopadhyay, Sourav
Ghosh, Totan
Tripathy, Satyajit
Das, Sabyasachi
Das, Debasis
Roy, Somenath
author_facet Dash, Sandeep Kumar
Chattopadhyay, Sourav
Ghosh, Totan
Tripathy, Satyajit
Das, Sabyasachi
Das, Debasis
Roy, Somenath
author_sort Dash, Sandeep Kumar
collection PubMed
description Transitional metals and metal compounds have been used in versatile platforms for biomedical applications and therapeutic intervention. Severe side effects of anticancer drugs produce an urgent urge to develop new classes of anticancer agents with great potency as well as selectivity. In this background, recent studies demonstrate that monomeric manganese (MnII) thiocyanate complex (MMTC) holds great promise to exert effective antileukemic effects. MMTC was developed by a simple chemical reaction and characterized by elemental analyses, thermal analyses, and Fourier transform infrared (FTIR) spectroscopy. Anti-leukemic efficacy of the developed MMTC was estimated in KG-1A (AML) and K562 (CML) cell lines. Cell viability study, drug uptake assay, cellular redox balance (GSH and GSSG level), nitric oxide (NO) release level, reactive oxygen species (ROS) formation, alteration of mitochondrial membrane potential (MMP), and DNA fragmentation revealed that MMTC was able to produce significant antiproliferative effects on both cell lines at 25 μg mL(−1) without showing any toxicological impact on normal lymphocytes. These findings will enlighten the biomedical application of manganese-based metal complexes as anti-leukemic agents.
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spelling pubmed-38177082013-11-12 Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines Dash, Sandeep Kumar Chattopadhyay, Sourav Ghosh, Totan Tripathy, Satyajit Das, Sabyasachi Das, Debasis Roy, Somenath ISRN Oncol Research Article Transitional metals and metal compounds have been used in versatile platforms for biomedical applications and therapeutic intervention. Severe side effects of anticancer drugs produce an urgent urge to develop new classes of anticancer agents with great potency as well as selectivity. In this background, recent studies demonstrate that monomeric manganese (MnII) thiocyanate complex (MMTC) holds great promise to exert effective antileukemic effects. MMTC was developed by a simple chemical reaction and characterized by elemental analyses, thermal analyses, and Fourier transform infrared (FTIR) spectroscopy. Anti-leukemic efficacy of the developed MMTC was estimated in KG-1A (AML) and K562 (CML) cell lines. Cell viability study, drug uptake assay, cellular redox balance (GSH and GSSG level), nitric oxide (NO) release level, reactive oxygen species (ROS) formation, alteration of mitochondrial membrane potential (MMP), and DNA fragmentation revealed that MMTC was able to produce significant antiproliferative effects on both cell lines at 25 μg mL(−1) without showing any toxicological impact on normal lymphocytes. These findings will enlighten the biomedical application of manganese-based metal complexes as anti-leukemic agents. Hindawi Publishing Corporation 2013-10-08 /pmc/articles/PMC3817708/ /pubmed/24223312 http://dx.doi.org/10.1155/2013/709269 Text en Copyright © 2013 Sandeep Kumar Dash et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dash, Sandeep Kumar
Chattopadhyay, Sourav
Ghosh, Totan
Tripathy, Satyajit
Das, Sabyasachi
Das, Debasis
Roy, Somenath
Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title_full Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title_fullStr Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title_full_unstemmed Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title_short Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
title_sort antileukemic efficacy of monomeric manganese-based metal complex on kg-1a and k562 cell lines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817708/
https://www.ncbi.nlm.nih.gov/pubmed/24223312
http://dx.doi.org/10.1155/2013/709269
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