The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells

The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was initially observed in leukemias, but subsequently al...

Descripción completa

Detalles Bibliográficos
Autores principales: Weber, Axel, Borghouts, Corina, Brendel, Christian, Moriggl, Richard, Delis, Natalia, Brill, Boris, Vafaizadeh, Vida, Groner, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817735/
https://www.ncbi.nlm.nih.gov/pubmed/24276378
http://dx.doi.org/10.3390/ph6080960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817735/
https://www.ncbi.nlm.nih.gov/pubmed/24276378
http://dx.doi.org/10.3390/ph6080960

Ejemplares similares