Stimulus-specific enhancement of fear extinction during slow-wave sleep

Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-spe...

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Detalles Bibliográficos
Autores principales: Hauner, K. K., Howard, J. D., Zelano, C., Gottfried, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818116/
https://www.ncbi.nlm.nih.gov/pubmed/24056700
http://dx.doi.org/10.1038/nn.3527
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author Hauner, K. K.
Howard, J. D.
Zelano, C.
Gottfried, J. A.
author_facet Hauner, K. K.
Howard, J. D.
Zelano, C.
Gottfried, J. A.
author_sort Hauner, K. K.
collection PubMed
description Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extinction, with parallel reductions of hippocampal activity and reorganization of amygdala ensemble patterns. Fear extinction may thus be selectively enhanced during sleep, even without re-exposure to the feared stimulus itself.
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spelling pubmed-38181162014-05-01 Stimulus-specific enhancement of fear extinction during slow-wave sleep Hauner, K. K. Howard, J. D. Zelano, C. Gottfried, J. A. Nat Neurosci Article Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extinction, with parallel reductions of hippocampal activity and reorganization of amygdala ensemble patterns. Fear extinction may thus be selectively enhanced during sleep, even without re-exposure to the feared stimulus itself. 2013-09-22 2013-11 /pmc/articles/PMC3818116/ /pubmed/24056700 http://dx.doi.org/10.1038/nn.3527 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hauner, K. K.
Howard, J. D.
Zelano, C.
Gottfried, J. A.
Stimulus-specific enhancement of fear extinction during slow-wave sleep
title Stimulus-specific enhancement of fear extinction during slow-wave sleep
title_full Stimulus-specific enhancement of fear extinction during slow-wave sleep
title_fullStr Stimulus-specific enhancement of fear extinction during slow-wave sleep
title_full_unstemmed Stimulus-specific enhancement of fear extinction during slow-wave sleep
title_short Stimulus-specific enhancement of fear extinction during slow-wave sleep
title_sort stimulus-specific enhancement of fear extinction during slow-wave sleep
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818116/
https://www.ncbi.nlm.nih.gov/pubmed/24056700
http://dx.doi.org/10.1038/nn.3527
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