A RhoC Biosensor Reveals Differences in the Activation Kinetics of RhoA and RhoC in Migrating Cells

RhoA and RhoC GTPases share 92% amino acid sequence identity, yet play different roles in regulating cell motility and morphology. To understand these differences, we developed and validated a biosensor of RhoC activation (RhoC FLARE). This was used together with a RhoA biosensor to compare the spat...

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Detalles Bibliográficos
Autores principales: Zawistowski, Jon S., Sabouri-Ghomi, Mohsen, Danuser, Gaudenz, Hahn, Klaus M., Hodgson, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818223/
https://www.ncbi.nlm.nih.gov/pubmed/24224016
http://dx.doi.org/10.1371/journal.pone.0079877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818223/
https://www.ncbi.nlm.nih.gov/pubmed/24224016
http://dx.doi.org/10.1371/journal.pone.0079877

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