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Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T(H)2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation
BACKGROUND: Severe asthma is associated with T helper (T(H)) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have be...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818233/ https://www.ncbi.nlm.nih.gov/pubmed/24223970 http://dx.doi.org/10.1371/journal.pone.0079565 |