Inhibiting AKT Phosphorylation Employing Non-Cytotoxic Anthraquinones Ameliorates T(H)2 Mediated Allergic Airways Disease and Rhinovirus Exacerbation

BACKGROUND: Severe asthma is associated with T helper (T(H)) 2 and 17 cell activation, airway neutrophilia and phosphoinositide-3-kinase (PI3K) activation. Asthma exacerbations are commonly caused by rhinovirus (RV) and also associated with PI3K-driven inflammation. Anthraquinone derivatives have be...

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Detalles Bibliográficos
Autores principales: Cesar de Souza Alves, Caio, Collison, Adam, Hatchwell, Luke, Plank, Maximilian, Morten, Matthew, Foster, Paul S., Johnston, Sebastian L., França da Costa, Cristiane, Vieira de Almeida, Mauro, Couto Teixeira, Henrique, Paula Ferreira, Ana, Mattes, Joerg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818233/
https://www.ncbi.nlm.nih.gov/pubmed/24223970
http://dx.doi.org/10.1371/journal.pone.0079565

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