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Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin
Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (ginseng saponins) are primarily responsible for the actions of ginseng. However, the effect...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818586/ https://www.ncbi.nlm.nih.gov/pubmed/24122014 http://dx.doi.org/10.1038/aps.2013.100 |
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author | Im, Dong-soon Nah, Seung-yeol |
author_facet | Im, Dong-soon Nah, Seung-yeol |
author_sort | Im, Dong-soon |
collection | PubMed |
description | Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (ginseng saponins) are primarily responsible for the actions of ginseng. However, the effects of ginseng are not fully explained by ginsenosides. Recently, another class of active ingredients called gintonin was identified. Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids (LPAs) that are the intracellular lipid mitogenic mediator. Gintonin specifically and potently activates the G protein-coupled receptors (GPCRs) for LPA. Thus, the actions of ginseng are now also linked to LPA and its GPCRs. This linkage opens new dimensions for ginseng pharmacology and LPA therapeutics. In the present review, we evaluate the pharmacology of ginseng with the traditional viewpoint of Yin and Yang components. Furthermore, we will compare ginsenoside and gintonin based on the modern view of molecular pharmacology in terms of ion channels and GPCRs. |
format | Online Article Text |
id | pubmed-3818586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38185862013-11-06 Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin Im, Dong-soon Nah, Seung-yeol Acta Pharmacol Sin Review Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (ginseng saponins) are primarily responsible for the actions of ginseng. However, the effects of ginseng are not fully explained by ginsenosides. Recently, another class of active ingredients called gintonin was identified. Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids (LPAs) that are the intracellular lipid mitogenic mediator. Gintonin specifically and potently activates the G protein-coupled receptors (GPCRs) for LPA. Thus, the actions of ginseng are now also linked to LPA and its GPCRs. This linkage opens new dimensions for ginseng pharmacology and LPA therapeutics. In the present review, we evaluate the pharmacology of ginseng with the traditional viewpoint of Yin and Yang components. Furthermore, we will compare ginsenoside and gintonin based on the modern view of molecular pharmacology in terms of ion channels and GPCRs. Nature Publishing Group 2013-11-05 2013-10-14 /pmc/articles/PMC3818586/ /pubmed/24122014 http://dx.doi.org/10.1038/aps.2013.100 Text en Copyright © 2013 CPS and SIMM http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Review Im, Dong-soon Nah, Seung-yeol Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title_full | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title_fullStr | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title_full_unstemmed | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title_short | Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin |
title_sort | yin and yang of ginseng pharmacology: ginsenosides vs gintonin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818586/ https://www.ncbi.nlm.nih.gov/pubmed/24122014 http://dx.doi.org/10.1038/aps.2013.100 |
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