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Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model

Using an in vivo cycling strategy, we selected metastatic cancer cells from the lymph nodes (LN) of mice bearing orthotopic DU145 human prostate tumors. Repeated rounds of metastatic selection (LN1–LN4) progressively increased the epithelial phenotype, resulting in a new model of tumor cell mesenchy...

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Detalles Bibliográficos
Autores principales: Banyard, Jacqueline, Chung, Ivy, Wilson, Arianne M., Vetter, Guillaume, Le Béchec, Antony, Bielenberg, Diane R., Zetter, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818652/
https://www.ncbi.nlm.nih.gov/pubmed/24193225
http://dx.doi.org/10.1038/srep03151