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Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism

BACKGROUND: Cardiovascular morbidities have been reported in hypothyroidism. AIMS: The objective of this study is to investigate the link of sympathovagal imbalance (SVI) to cardiovascular risks (CVRs) and the plausible mechanisms of CVR in hypothyroidism. MATERIALS AND METHODS: Age-matched 104 fema...

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Autores principales: Syamsunder, Avupati Naga, Pal, Gopal Krushna, Pal, Pravati, Kamalanathan, Chandrakasan Sadishkumar, Parija, Subhash Chandra, Nanda, Nivedita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818829/
https://www.ncbi.nlm.nih.gov/pubmed/24251274
http://dx.doi.org/10.4103/1947-2714.118921
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author Syamsunder, Avupati Naga
Pal, Gopal Krushna
Pal, Pravati
Kamalanathan, Chandrakasan Sadishkumar
Parija, Subhash Chandra
Nanda, Nivedita
author_facet Syamsunder, Avupati Naga
Pal, Gopal Krushna
Pal, Pravati
Kamalanathan, Chandrakasan Sadishkumar
Parija, Subhash Chandra
Nanda, Nivedita
author_sort Syamsunder, Avupati Naga
collection PubMed
description BACKGROUND: Cardiovascular morbidities have been reported in hypothyroidism. AIMS: The objective of this study is to investigate the link of sympathovagal imbalance (SVI) to cardiovascular risks (CVRs) and the plausible mechanisms of CVR in hypothyroidism. MATERIALS AND METHODS: Age-matched 104 females (50 controls, 54 hypothyroids) were recruited and their body mass index (BMI), cardiovascular parameters, autonomic function tests by spectral analysis of heart rate variability (HRV), heart rate response to standing, deep breathing and blood pressure response to isometric handgrip were studied. Thyroid profile, lipid profile, immunological and inflammatory markers were estimated and their association with low-frequency to the high-frequency ratio (LF-HF) of HRV, the marker of SVI was assessed by multivariate regression. RESULTS: Increased diastolic pressure, decreased HRV, increased LF-HF, dyslipidemia and increased high-sensitive C-reactive protein (hsCRP) were observed in hypothyroid patients and all these parameters had significant correlation with LF-HF. BMI had no significant association with LF-HF. Atherogenic index (β 1.144, P = 0.001) and hsCRP (b 0.578, P = 0.009) had independent contribution to LF-HF. LF-HF could significantly predict hypertension status (odds ratio 2.05, confidence interval 1.110-5.352, P = 0.008) in hypothyroid subjects. CONCLUSIONS: SVI due to sympathetic activation and vagal withdrawal occurs in hypothyroidism. Dyslipidemia and low-grade inflammation, but not obesity contribute to SVI and SVI contributes to cardiovascular risks.
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spelling pubmed-38188292013-11-18 Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism Syamsunder, Avupati Naga Pal, Gopal Krushna Pal, Pravati Kamalanathan, Chandrakasan Sadishkumar Parija, Subhash Chandra Nanda, Nivedita N Am J Med Sci Original Article BACKGROUND: Cardiovascular morbidities have been reported in hypothyroidism. AIMS: The objective of this study is to investigate the link of sympathovagal imbalance (SVI) to cardiovascular risks (CVRs) and the plausible mechanisms of CVR in hypothyroidism. MATERIALS AND METHODS: Age-matched 104 females (50 controls, 54 hypothyroids) were recruited and their body mass index (BMI), cardiovascular parameters, autonomic function tests by spectral analysis of heart rate variability (HRV), heart rate response to standing, deep breathing and blood pressure response to isometric handgrip were studied. Thyroid profile, lipid profile, immunological and inflammatory markers were estimated and their association with low-frequency to the high-frequency ratio (LF-HF) of HRV, the marker of SVI was assessed by multivariate regression. RESULTS: Increased diastolic pressure, decreased HRV, increased LF-HF, dyslipidemia and increased high-sensitive C-reactive protein (hsCRP) were observed in hypothyroid patients and all these parameters had significant correlation with LF-HF. BMI had no significant association with LF-HF. Atherogenic index (β 1.144, P = 0.001) and hsCRP (b 0.578, P = 0.009) had independent contribution to LF-HF. LF-HF could significantly predict hypertension status (odds ratio 2.05, confidence interval 1.110-5.352, P = 0.008) in hypothyroid subjects. CONCLUSIONS: SVI due to sympathetic activation and vagal withdrawal occurs in hypothyroidism. Dyslipidemia and low-grade inflammation, but not obesity contribute to SVI and SVI contributes to cardiovascular risks. Medknow Publications & Media Pvt Ltd 2013-09 /pmc/articles/PMC3818829/ /pubmed/24251274 http://dx.doi.org/10.4103/1947-2714.118921 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Syamsunder, Avupati Naga
Pal, Gopal Krushna
Pal, Pravati
Kamalanathan, Chandrakasan Sadishkumar
Parija, Subhash Chandra
Nanda, Nivedita
Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title_full Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title_fullStr Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title_full_unstemmed Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title_short Association of Sympathovagal Imbalance with Cardiovascular Risks in Overt Hypothyroidism
title_sort association of sympathovagal imbalance with cardiovascular risks in overt hypothyroidism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818829/
https://www.ncbi.nlm.nih.gov/pubmed/24251274
http://dx.doi.org/10.4103/1947-2714.118921
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