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Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease

Cardiovascular risk factors influence onset and progression of Alzheimer's disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. I...

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Autores principales: Donix, Markus, Scharf, Maria, Marschner, Kira, Werner, Annett, Sauer, Cathrin, Gerner, Antje, Nees, Josef A., Meyer, Shirin, Donix, Katharina L., Von Kummer, Rüdiger, Holthoff, Vjera A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818844/
https://www.ncbi.nlm.nih.gov/pubmed/24228185
http://dx.doi.org/10.1155/2013/108021
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author Donix, Markus
Scharf, Maria
Marschner, Kira
Werner, Annett
Sauer, Cathrin
Gerner, Antje
Nees, Josef A.
Meyer, Shirin
Donix, Katharina L.
Von Kummer, Rüdiger
Holthoff, Vjera A.
author_facet Donix, Markus
Scharf, Maria
Marschner, Kira
Werner, Annett
Sauer, Cathrin
Gerner, Antje
Nees, Josef A.
Meyer, Shirin
Donix, Katharina L.
Von Kummer, Rüdiger
Holthoff, Vjera A.
author_sort Donix, Markus
collection PubMed
description Cardiovascular risk factors influence onset and progression of Alzheimer's disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer's disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors. We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer's disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer's disease, and age did not influence cortical thickness. Alzheimer's disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer's disease.
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spelling pubmed-38188442013-11-13 Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease Donix, Markus Scharf, Maria Marschner, Kira Werner, Annett Sauer, Cathrin Gerner, Antje Nees, Josef A. Meyer, Shirin Donix, Katharina L. Von Kummer, Rüdiger Holthoff, Vjera A. Int J Alzheimers Dis Research Article Cardiovascular risk factors influence onset and progression of Alzheimer's disease. Among cognitively healthy people, changes in brain structure and function associated with high blood pressure, diabetes, or other vascular risks suggest differential regional susceptibility to neuronal damage. In patients with Alzheimer's disease, hippocampal and medial temporal lobe atrophy indicate early neuronal loss preferentially in key areas for learning and memory. We wanted to investigate whether this regional cortical thinning would be modulated by cardiovascular risk factors. We utilized high-resolution magnetic resonance imaging and a cortical unfolding technique to determine the cortical thickness of medial temporal subregions in 30 patients with Alzheimer's disease. Cardiovascular risk was assessed using a sex-specific multivariable risk score. Greater cardiovascular risk was associated with cortical thinning in the hippocampus CA2/3/dentate gyrus area but not other hippocampal and medial temporal subregions. APOE genotype, a family history of Alzheimer's disease, and age did not influence cortical thickness. Alzheimer's disease-related atrophy could mask the influence of genetic risk factors or age on regional cortical thickness in medial temporal lobe regions, whereas the impact of vascular risk factors remains detectable. This highlights the importance of cardiovascular disease prevention and treatment in patients with Alzheimer's disease. Hindawi Publishing Corporation 2013 2013-10-21 /pmc/articles/PMC3818844/ /pubmed/24228185 http://dx.doi.org/10.1155/2013/108021 Text en Copyright © 2013 Markus Donix et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Donix, Markus
Scharf, Maria
Marschner, Kira
Werner, Annett
Sauer, Cathrin
Gerner, Antje
Nees, Josef A.
Meyer, Shirin
Donix, Katharina L.
Von Kummer, Rüdiger
Holthoff, Vjera A.
Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title_full Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title_fullStr Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title_full_unstemmed Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title_short Cardiovascular Risk and Hippocampal Thickness in Alzheimer's Disease
title_sort cardiovascular risk and hippocampal thickness in alzheimer's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818844/
https://www.ncbi.nlm.nih.gov/pubmed/24228185
http://dx.doi.org/10.1155/2013/108021
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