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The chromomycin CmmA acetyltransferase: a membrane‐bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

Mithramycin and chromomycin A(3) are two structurally related antitumour compounds, which differ in the glycosylation profiles and functional group substitutions of the sugars. Chromomycin contains two acetyl groups, which are incorporated during the biosynthesis by the acetyltransferase CmmA in Str...

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Detalles Bibliográficos
Autores principales: García, Beatriz, González‐Sabín, Javier, Menéndez, Nuria, Braña, Alfredo F., Núñez, Luz Elena, Morís, Francisco, Salas, José A., Méndez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818863/
https://www.ncbi.nlm.nih.gov/pubmed/21342468
http://dx.doi.org/10.1111/j.1751-7915.2010.00229.x