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The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery
BACKGROUND: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB)....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819002/ https://www.ncbi.nlm.nih.gov/pubmed/24161078 http://dx.doi.org/10.1186/1749-8090-8-199 |
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author | Hinz, José Schöndorf, Daniel Bireta, Christian Lipke, Christina Moerer, Onnen Bergmann, Ingo Wiese, Christoph Herman Mansur, Ashham Schotola, Hanna Sabashnikov, Anton Quintel, Michael Schoendube, Friedrich Albert Popov, Aron Frederik |
author_facet | Hinz, José Schöndorf, Daniel Bireta, Christian Lipke, Christina Moerer, Onnen Bergmann, Ingo Wiese, Christoph Herman Mansur, Ashham Schotola, Hanna Sabashnikov, Anton Quintel, Michael Schoendube, Friedrich Albert Popov, Aron Frederik |
author_sort | Hinz, José |
collection | PubMed |
description | BACKGROUND: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality. METHOD: 500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification. RESULTS: Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups. CONCLUSION: Our results show that the eNOS 894G /T polymorphism is not associated with early and late clinical outcome after cardiac surgery. Thus, this polymorphism can actually not help to identify high risk groups in the heterogeneous population of individuals who undergo cardiac surgery with CPB. |
format | Online Article Text |
id | pubmed-3819002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-38190022013-11-07 The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery Hinz, José Schöndorf, Daniel Bireta, Christian Lipke, Christina Moerer, Onnen Bergmann, Ingo Wiese, Christoph Herman Mansur, Ashham Schotola, Hanna Sabashnikov, Anton Quintel, Michael Schoendube, Friedrich Albert Popov, Aron Frederik J Cardiothorac Surg Research Article BACKGROUND: The eNOS 894G/T polymorphism (GG, GT, and TT) is associated with cardiovascular mortality and may influence cardiovascular diseases as a genetic risk factor. Moreover, this polymorphism has an impact on intraoperative hemodynamics during cardiac surgery with cardiopulmonary bypass (CPB). In this study, we analyzed the influence of this gene polymorphism on early clinical outcome in patients who underwent cardiac surgery with CPB. Also, we performed a 5-year follow-up, assessing the impact of this polymorphism on long-term mortality. METHOD: 500 patients who underwent cardiac surgery with CPB between 2006 and 2007 were included in this prospective single centre study. Genotyping for the eNOS gene polymorphism was performed by polymerase chain reaction amplification. RESULTS: Genotype distribution of 894G/T was: GG 50.2%; GT 42.2%; TT 7.8%. Cardiovascular risk factors were equally distributed between the different genotypes of the eNOS 894G/T polymorphism. No significant difference among the groups was shown regarding Euroscore, SAPS II and APACHE II. Perioperative characteristics were also not affected by the genotypes, except for the consumption of norepinephrine (p = 0.03) and amiodarone (p = 0.01) which was higher in the GT allele carrier. The early postoperative course was quite uniform across the genotypes, except for mean intensive care unit length of stay which was significantly prolonged in GT carriers (p = 0.001). The five-year follow-up was 100% complete and showed no significant differences regarding mortality between the groups. CONCLUSION: Our results show that the eNOS 894G /T polymorphism is not associated with early and late clinical outcome after cardiac surgery. Thus, this polymorphism can actually not help to identify high risk groups in the heterogeneous population of individuals who undergo cardiac surgery with CPB. BioMed Central 2013-10-25 /pmc/articles/PMC3819002/ /pubmed/24161078 http://dx.doi.org/10.1186/1749-8090-8-199 Text en Copyright © 2013 Hinz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hinz, José Schöndorf, Daniel Bireta, Christian Lipke, Christina Moerer, Onnen Bergmann, Ingo Wiese, Christoph Herman Mansur, Ashham Schotola, Hanna Sabashnikov, Anton Quintel, Michael Schoendube, Friedrich Albert Popov, Aron Frederik The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title | The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title_full | The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title_fullStr | The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title_full_unstemmed | The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title_short | The eNOS 894G/T gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
title_sort | enos 894g/t gene polymorphism and its influence on early and long-term mortality after on-pump cardiac surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819002/ https://www.ncbi.nlm.nih.gov/pubmed/24161078 http://dx.doi.org/10.1186/1749-8090-8-199 |
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