Addition of Exogenous NAD(+) Prevents Mefloquine-Induced Neuroaxonal and Hair Cell Degeneration through Reduction of Caspase-3-Mediated Apoptosis in Cochlear Organotypic Cultures

BACKGROUND: Mefloquine is widely used for the treatment of malaria. However, this drug is known to induce neurological side effects including depression, anxiety, balance disorder, and sensorineural hearing loss. Yet, there is currently no treatment for these side effects. PRINCIPAL FINDINGS: In thi...

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Detalles Bibliográficos
Autores principales: Ding, Dalian, Qi, Weidong, Yu, Dongzhen, Jiang, Haiyan, Han, Chul, Kim, Mi-Jung, Katsuno, Kana, Hsieh, Yun Hua, Miyakawa, Takuya, Salvi, Richard, Tanokura, Masaru, Someya, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819247/
https://www.ncbi.nlm.nih.gov/pubmed/24223197
http://dx.doi.org/10.1371/journal.pone.0079817

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