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The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s
OBJECTIVES: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. METHODS: Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG)...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819312/ https://www.ncbi.nlm.nih.gov/pubmed/23807275 http://dx.doi.org/10.1097/QAD.0b013e328360db2d |
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author | Feng, Yi He, Xiang Hsi, Jenny H. Li, Fan Li, Xingguang Wang, Quan Ruan, Yuhua Xing, Hui Lam, Tommy Tsan-Yuk Pybus, Oliver G. Takebe, Yutaka Shao, Yiming |
author_facet | Feng, Yi He, Xiang Hsi, Jenny H. Li, Fan Li, Xingguang Wang, Quan Ruan, Yuhua Xing, Hui Lam, Tommy Tsan-Yuk Pybus, Oliver G. Takebe, Yutaka Shao, Yiming |
author_sort | Feng, Yi |
collection | PubMed |
description | OBJECTIVES: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. METHODS: Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China. RESULTS: We generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country. CONCLUSION: China's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B′ strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission. |
format | Online Article Text |
id | pubmed-3819312 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-38193122013-11-13 The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s Feng, Yi He, Xiang Hsi, Jenny H. Li, Fan Li, Xingguang Wang, Quan Ruan, Yuhua Xing, Hui Lam, Tommy Tsan-Yuk Pybus, Oliver G. Takebe, Yutaka Shao, Yiming AIDS Epidemiology and Social OBJECTIVES: We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. METHODS: Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China. RESULTS: We generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country. CONCLUSION: China's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B′ strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission. Lippincott Williams & Wilkins 2013-07-17 2013-07-03 /pmc/articles/PMC3819312/ /pubmed/23807275 http://dx.doi.org/10.1097/QAD.0b013e328360db2d Text en © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. |
spellingShingle | Epidemiology and Social Feng, Yi He, Xiang Hsi, Jenny H. Li, Fan Li, Xingguang Wang, Quan Ruan, Yuhua Xing, Hui Lam, Tommy Tsan-Yuk Pybus, Oliver G. Takebe, Yutaka Shao, Yiming The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title_full | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title_fullStr | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title_full_unstemmed | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title_short | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s |
title_sort | rapidly expanding crf01_ae epidemic in china is driven by multiple lineages of hiv-1 viruses introduced in the 1990s |
topic | Epidemiology and Social |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819312/ https://www.ncbi.nlm.nih.gov/pubmed/23807275 http://dx.doi.org/10.1097/QAD.0b013e328360db2d |
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