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Quantitative Analysis of PiB-PET with FreeSurfer ROIs

In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use ma...

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Autores principales: Su, Yi, D'Angelo, Gina M., Vlassenko, Andrei G., Zhou, Gongfu, Snyder, Abraham Z., Marcus, Daniel S., Blazey, Tyler M., Christensen, Jon J., Vora, Shivangi, Morris, John C., Mintun, Mark A., Benzinger, Tammie L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819320/
https://www.ncbi.nlm.nih.gov/pubmed/24223109
http://dx.doi.org/10.1371/journal.pone.0073377
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author Su, Yi
D'Angelo, Gina M.
Vlassenko, Andrei G.
Zhou, Gongfu
Snyder, Abraham Z.
Marcus, Daniel S.
Blazey, Tyler M.
Christensen, Jon J.
Vora, Shivangi
Morris, John C.
Mintun, Mark A.
Benzinger, Tammie L. S.
author_facet Su, Yi
D'Angelo, Gina M.
Vlassenko, Andrei G.
Zhou, Gongfu
Snyder, Abraham Z.
Marcus, Daniel S.
Blazey, Tyler M.
Christensen, Jon J.
Vora, Shivangi
Morris, John C.
Mintun, Mark A.
Benzinger, Tammie L. S.
author_sort Su, Yi
collection PubMed
description In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions.
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spelling pubmed-38193202013-11-12 Quantitative Analysis of PiB-PET with FreeSurfer ROIs Su, Yi D'Angelo, Gina M. Vlassenko, Andrei G. Zhou, Gongfu Snyder, Abraham Z. Marcus, Daniel S. Blazey, Tyler M. Christensen, Jon J. Vora, Shivangi Morris, John C. Mintun, Mark A. Benzinger, Tammie L. S. PLoS One Research Article In vivo quantification of β-amyloid deposition using positron emission tomography is emerging as an important procedure for the early diagnosis of the Alzheimer's disease and is likely to play an important role in upcoming clinical trials of disease modifying agents. However, many groups use manually defined regions, which are non-standard across imaging centers. Analyses often are limited to a handful of regions because of the labor-intensive nature of manual region drawing. In this study, we developed an automatic image quantification protocol based on FreeSurfer, an automated whole brain segmentation tool, for quantitative analysis of amyloid images. Standard manual tracing and FreeSurfer-based analyses were performed in 77 participants including 67 cognitively normal individuals and 10 individuals with early Alzheimer's disease. The manual and FreeSurfer approaches yielded nearly identical estimates of amyloid burden (intraclass correlation = 0.98) as assessed by the mean cortical binding potential. An MRI test-retest study demonstrated excellent reliability of FreeSurfer based regional amyloid burden measurements. The FreeSurfer-based analysis also revealed that the majority of cerebral cortical regions accumulate amyloid in parallel, with slope of accumulation being the primary difference between regions. Public Library of Science 2013-11-06 /pmc/articles/PMC3819320/ /pubmed/24223109 http://dx.doi.org/10.1371/journal.pone.0073377 Text en © 2013 Su et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Su, Yi
D'Angelo, Gina M.
Vlassenko, Andrei G.
Zhou, Gongfu
Snyder, Abraham Z.
Marcus, Daniel S.
Blazey, Tyler M.
Christensen, Jon J.
Vora, Shivangi
Morris, John C.
Mintun, Mark A.
Benzinger, Tammie L. S.
Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title_full Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title_fullStr Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title_full_unstemmed Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title_short Quantitative Analysis of PiB-PET with FreeSurfer ROIs
title_sort quantitative analysis of pib-pet with freesurfer rois
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819320/
https://www.ncbi.nlm.nih.gov/pubmed/24223109
http://dx.doi.org/10.1371/journal.pone.0073377
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