Cargando…

An Over Expression APP Model for Anti-Alzheimer Disease Drug Screening Created by Zinc Finger Nuclease Technology

Zinc Finger Nucleases (ZFNs), famous for their ability to precisely and efficiently modify specific genomic loci, have been employed in numerous transgenic model organism and cell constructions. Here we employ the ZFNs technology, with homologous recombination (HR), to construct sequence-specific Am...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaojing, Li, Hui, Mao, Yiqing, Li, Zhixin, Wang, Rong, Guo, Tingting, Jin, Ling, Song, Rongjing, Xu, Wei, Zhou, Na, Zhang, Yizhuang, Hu, Ruobi, Wang, Xi, Huang, Huakang, Lei, Zhen, Niu, Gang, Irwin, David M., Tan, Huanran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819351/ https://www.ncbi.nlm.nih.gov/pubmed/24223114 http://dx.doi.org/10.1371/journal.pone.0075493

Ejemplares similares

Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein
por: Jin, Ling, et al.
Publicado: (2015)

Differential Expression of Genes Associated with the Progression of Renal Disease in the Kidneys of Liver-Specific Glucokinase Gene Knockout Mice
por: Xu, Wei, et al.
Publicado: (2013)

Exposure of Tumor-Associated Macrophages to Apoptotic MCF-7 Cells Promotes Breast Cancer Growth and Metastasis
por: Zhou, Na, et al.
Publicado: (2015)

Zhou, N., et al. Exposure of Tumor-Associated Macrophages to ApoptoticMCF-7 Cells Promotes Breast Cancer Growth and Metastasis. Int. J. Mol. Sci. 2015, 16, 11966–11982
por: Zhou, Na, et al.
Publicado: (2015)

Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM
por: Zhou, Na, et al.
Publicado: (2015)

Simultaneous Screening and Validation of Effective Zinc Finger Nucleases in Yeast
por: Wang, Ling, et al.
Publicado: (2013)

Knockout of Myostatin by Zinc-finger Nuclease in Sheep Fibroblasts and Embryos
por: Zhang, Xuemei, et al.
Publicado: (2016)

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK
por: Li, Hui, et al.
Publicado: (2014)

Tumacrophage: macrophages transformed into tumor stem-like cells by virulent genetic material from tumor cells
por: Zhang, Yizhuang, et al.
Publicado: (2017)

Using defined finger–finger interfaces as units of assembly for constructing zinc-finger nucleases
por: Zhu, Cong, et al.
Publicado: (2013)

Targeted genome engineering via zinc finger nucleases
por: Kim, Seokjoong, et al.
Publicado: (2010)

Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases
por: Gupta, Ankit, et al.
Publicado: (2011)

Design and Development of Artificial Zinc Finger Transcription Factors and Zinc Finger Nucleases to the hTERT Locus
por: Wilson, Kimberly A, et al.
Publicado: (2013)

A Novel Genetic System Based on Zinc Finger Nucleases for the Identification of Interactions between Proteins In Vivo
por: Wang, Ling, et al.
Publicado: (2013)

Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila
por: Beumer, Kelly J., et al.
Publicado: (2013)

Diversifying the structure of zinc finger nucleases for high-precision genome editing
por: Paschon, David E., et al.
Publicado: (2019)

Zinc Finger Nucleases as tools to understand and treat human diseases
por: Davis, David, et al.
Publicado: (2010)

Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
por: Şöllü, Cem, et al.
Publicado: (2010)

Highly active zinc-finger nucleases by extended modular assembly
por: Bhakta, Mital S., et al.
Publicado: (2013)

Zinc Finger Nucleases: A new era for transgenic animals
por: Swarthout, John T., et al.
Publicado: (2011)

Genome editing in plants via designed zinc finger nucleases
por: Petolino, Joseph F.
Publicado: (2015)

Evaluating the effect of chromosomal context on zinc finger nuclease efficiency
por: Bahr, Scott, et al.
Publicado: (2013)

Cancer translocations in human cells induced by zinc finger and TALE nucleases
por: Piganeau, Marion, et al.
Publicado: (2013)

Efficient Generation of Myostatin (MSTN) Biallelic Mutations in Cattle Using Zinc Finger Nucleases
por: Luo, Junjie, et al.
Publicado: (2014)

Disruption of the Myostatin Gene in Porcine Primary Fibroblasts and Embryos Using Zinc-Finger Nucleases
por: Huang, Xian-Ju, et al.
Publicado: (2014)

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
por: Yang, Dongshan, et al.
Publicado: (2013)

Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
por: Wilson, Kimberly A, et al.
Publicado: (2013)

Donor DNA Utilization During Gene Targeting with Zinc-Finger Nucleases
por: Beumer, Kelly J., et al.
Publicado: (2013)

Gene Targeting in NOD Mouse Embryos Using Zinc-Finger Nucleases
por: Chen, Yi-Guang, et al.
Publicado: (2014)

Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases
por: Merlin, Christine, et al.
Publicado: (2013)

Application of a TLR overexpression cell model in pyrogen detection
por: Han, Qing, et al.
Publicado: (2019)

Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases
por: Doyon, Yannick, et al.
Publicado: (2008)

Expression of the Human Glucokinase Gene: Important Roles of the 5′ Flanking and Intron 1 Sequences
por: Wang, Yi, et al.
Publicado: (2012)

Targeted Deletion and Inversion of Tandemly Arrayed Genes in Arabidopsis thaliana Using Zinc Finger Nucleases
por: Qi, Yiping, et al.
Publicado: (2013)

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs
por: Qian, Lili, et al.
Publicado: (2015)

Efficient Knockin Mouse Generation by ssDNA Oligonucleotides and Zinc-Finger Nuclease Assisted Homologous Recombination in Zygotes
por: Shen, Bin, et al.
Publicado: (2013)

Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases
por: Mandell, Jeffrey G., et al.
Publicado: (2006)

Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection
por: Pattanayak, Vikram, et al.
Publicado: (2011)

Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
por: Pruett-Miller, Shondra M., et al.
Publicado: (2009)

High frequency modification of plant genes using engineered zinc finger nucleases
por: Townsend, Jeffrey A., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_kp20evovasn95i9jeo4iqeb5qd