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Aging Brain from a Network Science Perspective: Something to Be Positive About?
To better understand age differences in brain function and behavior, the current study applied network science to model functional interactions between brain regions. We observed a shift in network topology whereby for older adults subcortical and cerebellar structures overlapping with the Salience...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819386/ https://www.ncbi.nlm.nih.gov/pubmed/24223147 http://dx.doi.org/10.1371/journal.pone.0078345 |
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author | Voss, Michelle W. Wong, Chelsea N. Baniqued, Pauline L. Burdette, Jonathan H. Erickson, Kirk I. Prakash, Ruchika Shaurya McAuley, Edward Laurienti, Paul J. Kramer, Arthur F. |
author_facet | Voss, Michelle W. Wong, Chelsea N. Baniqued, Pauline L. Burdette, Jonathan H. Erickson, Kirk I. Prakash, Ruchika Shaurya McAuley, Edward Laurienti, Paul J. Kramer, Arthur F. |
author_sort | Voss, Michelle W. |
collection | PubMed |
description | To better understand age differences in brain function and behavior, the current study applied network science to model functional interactions between brain regions. We observed a shift in network topology whereby for older adults subcortical and cerebellar structures overlapping with the Salience network had more connectivity to the rest of the brain, coupled with fragmentation of large-scale cortical networks such as the Default and Fronto-Parietal networks. Additionally, greater integration of the dorsal medial thalamus and red nucleus in the Salience network was associated with greater satisfaction with life for older adults, which is consistent with theoretical predictions of age-related increases in emotion regulation that are thought to help maintain well-being and life satisfaction in late adulthood. In regard to cognitive abilities, greater ventral medial prefrontal cortex coherence with its topological neighbors in the Default Network was associated with faster processing speed. Results suggest that large-scale organizing properties of the brain differ with normal aging, and this perspective may offer novel insight into understanding age-related differences in cognitive function and well-being. |
format | Online Article Text |
id | pubmed-3819386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38193862013-11-12 Aging Brain from a Network Science Perspective: Something to Be Positive About? Voss, Michelle W. Wong, Chelsea N. Baniqued, Pauline L. Burdette, Jonathan H. Erickson, Kirk I. Prakash, Ruchika Shaurya McAuley, Edward Laurienti, Paul J. Kramer, Arthur F. PLoS One Research Article To better understand age differences in brain function and behavior, the current study applied network science to model functional interactions between brain regions. We observed a shift in network topology whereby for older adults subcortical and cerebellar structures overlapping with the Salience network had more connectivity to the rest of the brain, coupled with fragmentation of large-scale cortical networks such as the Default and Fronto-Parietal networks. Additionally, greater integration of the dorsal medial thalamus and red nucleus in the Salience network was associated with greater satisfaction with life for older adults, which is consistent with theoretical predictions of age-related increases in emotion regulation that are thought to help maintain well-being and life satisfaction in late adulthood. In regard to cognitive abilities, greater ventral medial prefrontal cortex coherence with its topological neighbors in the Default Network was associated with faster processing speed. Results suggest that large-scale organizing properties of the brain differ with normal aging, and this perspective may offer novel insight into understanding age-related differences in cognitive function and well-being. Public Library of Science 2013-11-06 /pmc/articles/PMC3819386/ /pubmed/24223147 http://dx.doi.org/10.1371/journal.pone.0078345 Text en © 2013 Voss et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Voss, Michelle W. Wong, Chelsea N. Baniqued, Pauline L. Burdette, Jonathan H. Erickson, Kirk I. Prakash, Ruchika Shaurya McAuley, Edward Laurienti, Paul J. Kramer, Arthur F. Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title | Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title_full | Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title_fullStr | Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title_full_unstemmed | Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title_short | Aging Brain from a Network Science Perspective: Something to Be Positive About? |
title_sort | aging brain from a network science perspective: something to be positive about? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819386/ https://www.ncbi.nlm.nih.gov/pubmed/24223147 http://dx.doi.org/10.1371/journal.pone.0078345 |
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