Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses

Autism spectrum disorders (ASD) are highly heritable, yet genetically heterogeneous neurodevelopmental conditions. Recent genome-wide association and gene expression studies have provided evidence supporting the notion that the large number of genetic variants associated with ASD converge toward a c...

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Detalles Bibliográficos
Autores principales: Voineagu, Irina, Eapen, Valsamma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819618/
https://www.ncbi.nlm.nih.gov/pubmed/24223544
http://dx.doi.org/10.3389/fnhum.2013.00738
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author Voineagu, Irina
Eapen, Valsamma
author_facet Voineagu, Irina
Eapen, Valsamma
author_sort Voineagu, Irina
collection PubMed
description Autism spectrum disorders (ASD) are highly heritable, yet genetically heterogeneous neurodevelopmental conditions. Recent genome-wide association and gene expression studies have provided evidence supporting the notion that the large number of genetic variants associated with ASD converge toward a core set of dysregulated biological processes. Here we review recent data demonstrating the involvement of synaptic dysfunction and abnormal immune responses in ASD, and discuss the functional interplay between the two phenomena.
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spelling pubmed-38196182013-11-09 Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses Voineagu, Irina Eapen, Valsamma Front Hum Neurosci Neuroscience Autism spectrum disorders (ASD) are highly heritable, yet genetically heterogeneous neurodevelopmental conditions. Recent genome-wide association and gene expression studies have provided evidence supporting the notion that the large number of genetic variants associated with ASD converge toward a core set of dysregulated biological processes. Here we review recent data demonstrating the involvement of synaptic dysfunction and abnormal immune responses in ASD, and discuss the functional interplay between the two phenomena. Frontiers Media S.A. 2013-11-07 /pmc/articles/PMC3819618/ /pubmed/24223544 http://dx.doi.org/10.3389/fnhum.2013.00738 Text en Copyright © 2013 Voineagu and Eapen. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Voineagu, Irina
Eapen, Valsamma
Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title_full Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title_fullStr Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title_full_unstemmed Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title_short Converging Pathways in Autism Spectrum Disorders: Interplay between Synaptic Dysfunction and Immune Responses
title_sort converging pathways in autism spectrum disorders: interplay between synaptic dysfunction and immune responses
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819618/
https://www.ncbi.nlm.nih.gov/pubmed/24223544
http://dx.doi.org/10.3389/fnhum.2013.00738
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