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Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation

Renal mucormycosis is a rare and potentially lethal complication of kidney transplantation. We describe two cases of renal mucormycosis following deceased donor kidney transplantation. This is the second report of renal mucormycosis following kidney transplantation in the United States, and the firs...

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Autores principales: Kuy, SreyRam, He, Chun, Cronin, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819800/
https://www.ncbi.nlm.nih.gov/pubmed/24251062
http://dx.doi.org/10.1155/2013/915423
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author Kuy, SreyRam
He, Chun
Cronin, David C.
author_facet Kuy, SreyRam
He, Chun
Cronin, David C.
author_sort Kuy, SreyRam
collection PubMed
description Renal mucormycosis is a rare and potentially lethal complication of kidney transplantation. We describe two cases of renal mucormycosis following deceased donor kidney transplantation. This is the second report of renal mucormycosis following kidney transplantation in the United States, and the first case of renal mucormycosis infection presumed to be of recipient origin. Case A had an early presentation of mucormycosis isolated to the kidney allograft. He had an unexpected rise in serum creatinine and leukocytosis necessitating allograft biopsy which showed mucormycosis. He underwent transplant nephrectomy on posttransplant day 11, was treated with amphotericin B, and discharged home on posttransplant day 22. Case B had a late presentation of renal mucormycosis, preceded by a cutaneous manifestation. One year after kidney transplantation he had a nonhealing knee ulcer which on biopsy showed cutaneous mucormycosis. Treatment included aggressive debridement and amphotericin B. Allograft biopsy showed mucormycosis, necessitating transplant nephrectomy. He was discharged to a rehabilitation facility and died from noninfectious causes. Review of the published literature of renal mucormycosis cases following kidney transplantation reveals a mortality rate of more than 50%. The key to successful outcome is early recognition, prompt institution of surgical debridement of all infected tissue, and appropriate antifungal therapy.
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spelling pubmed-38198002013-11-18 Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation Kuy, SreyRam He, Chun Cronin, David C. Case Rep Transplant Case Report Renal mucormycosis is a rare and potentially lethal complication of kidney transplantation. We describe two cases of renal mucormycosis following deceased donor kidney transplantation. This is the second report of renal mucormycosis following kidney transplantation in the United States, and the first case of renal mucormycosis infection presumed to be of recipient origin. Case A had an early presentation of mucormycosis isolated to the kidney allograft. He had an unexpected rise in serum creatinine and leukocytosis necessitating allograft biopsy which showed mucormycosis. He underwent transplant nephrectomy on posttransplant day 11, was treated with amphotericin B, and discharged home on posttransplant day 22. Case B had a late presentation of renal mucormycosis, preceded by a cutaneous manifestation. One year after kidney transplantation he had a nonhealing knee ulcer which on biopsy showed cutaneous mucormycosis. Treatment included aggressive debridement and amphotericin B. Allograft biopsy showed mucormycosis, necessitating transplant nephrectomy. He was discharged to a rehabilitation facility and died from noninfectious causes. Review of the published literature of renal mucormycosis cases following kidney transplantation reveals a mortality rate of more than 50%. The key to successful outcome is early recognition, prompt institution of surgical debridement of all infected tissue, and appropriate antifungal therapy. Hindawi Publishing Corporation 2013 2013-10-22 /pmc/articles/PMC3819800/ /pubmed/24251062 http://dx.doi.org/10.1155/2013/915423 Text en Copyright © 2013 SreyRam Kuy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kuy, SreyRam
He, Chun
Cronin, David C.
Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title_full Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title_fullStr Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title_full_unstemmed Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title_short Renal Mucormycosis: A Rare and Potentially Lethal Complication of Kidney Transplantation
title_sort renal mucormycosis: a rare and potentially lethal complication of kidney transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819800/
https://www.ncbi.nlm.nih.gov/pubmed/24251062
http://dx.doi.org/10.1155/2013/915423
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