Cargando…
Role of Gap Junctions and Hemichannels in Parasitic Infections
In vertebrates, connexins (Cxs) and pannexins (Panxs) are proteins that form gap junction channels and/or hemichannels located at cell-cell interfaces and cell surface, respectively. Similar channel types are formed by innexins in invertebrate cells. These channels serve as pathways for cellular com...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819887/ https://www.ncbi.nlm.nih.gov/pubmed/24236292 http://dx.doi.org/10.1155/2013/589130 |
_version_ | 1782290056901296128 |
---|---|
author | Vega, José Luis Subiabre, Mario Figueroa, Felipe Schalper, Kurt Alex Osorio, Luis González, Jorge Sáez, Juan Carlos |
author_facet | Vega, José Luis Subiabre, Mario Figueroa, Felipe Schalper, Kurt Alex Osorio, Luis González, Jorge Sáez, Juan Carlos |
author_sort | Vega, José Luis |
collection | PubMed |
description | In vertebrates, connexins (Cxs) and pannexins (Panxs) are proteins that form gap junction channels and/or hemichannels located at cell-cell interfaces and cell surface, respectively. Similar channel types are formed by innexins in invertebrate cells. These channels serve as pathways for cellular communication that coordinate diverse physiologic processes. However, it is known that many acquired and inherited diseases deregulate Cx and/or Panx channels, condition that frequently worsens the pathological state of vertebrates. Recent evidences suggest that Cx and/or Panx hemichannels play a relevant role in bacterial and viral infections. Nonetheless, little is known about the role of Cx- and Panx-based channels in parasitic infections of vertebrates. In this review, available data on changes in Cx and gap junction channel changes induced by parasitic infections are summarized. Additionally, we describe recent findings that suggest possible roles of hemichannels in parasitic infections. Finally, the possibility of new therapeutic designs based on hemichannel blokers is presented. |
format | Online Article Text |
id | pubmed-3819887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38198872013-11-14 Role of Gap Junctions and Hemichannels in Parasitic Infections Vega, José Luis Subiabre, Mario Figueroa, Felipe Schalper, Kurt Alex Osorio, Luis González, Jorge Sáez, Juan Carlos Biomed Res Int Review Article In vertebrates, connexins (Cxs) and pannexins (Panxs) are proteins that form gap junction channels and/or hemichannels located at cell-cell interfaces and cell surface, respectively. Similar channel types are formed by innexins in invertebrate cells. These channels serve as pathways for cellular communication that coordinate diverse physiologic processes. However, it is known that many acquired and inherited diseases deregulate Cx and/or Panx channels, condition that frequently worsens the pathological state of vertebrates. Recent evidences suggest that Cx and/or Panx hemichannels play a relevant role in bacterial and viral infections. Nonetheless, little is known about the role of Cx- and Panx-based channels in parasitic infections of vertebrates. In this review, available data on changes in Cx and gap junction channel changes induced by parasitic infections are summarized. Additionally, we describe recent findings that suggest possible roles of hemichannels in parasitic infections. Finally, the possibility of new therapeutic designs based on hemichannel blokers is presented. Hindawi Publishing Corporation 2013 2013-10-23 /pmc/articles/PMC3819887/ /pubmed/24236292 http://dx.doi.org/10.1155/2013/589130 Text en Copyright © 2013 José Luis Vega et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vega, José Luis Subiabre, Mario Figueroa, Felipe Schalper, Kurt Alex Osorio, Luis González, Jorge Sáez, Juan Carlos Role of Gap Junctions and Hemichannels in Parasitic Infections |
title | Role of Gap Junctions and Hemichannels in Parasitic Infections |
title_full | Role of Gap Junctions and Hemichannels in Parasitic Infections |
title_fullStr | Role of Gap Junctions and Hemichannels in Parasitic Infections |
title_full_unstemmed | Role of Gap Junctions and Hemichannels in Parasitic Infections |
title_short | Role of Gap Junctions and Hemichannels in Parasitic Infections |
title_sort | role of gap junctions and hemichannels in parasitic infections |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819887/ https://www.ncbi.nlm.nih.gov/pubmed/24236292 http://dx.doi.org/10.1155/2013/589130 |
work_keys_str_mv | AT vegajoseluis roleofgapjunctionsandhemichannelsinparasiticinfections AT subiabremario roleofgapjunctionsandhemichannelsinparasiticinfections AT figueroafelipe roleofgapjunctionsandhemichannelsinparasiticinfections AT schalperkurtalex roleofgapjunctionsandhemichannelsinparasiticinfections AT osorioluis roleofgapjunctionsandhemichannelsinparasiticinfections AT gonzalezjorge roleofgapjunctionsandhemichannelsinparasiticinfections AT saezjuancarlos roleofgapjunctionsandhemichannelsinparasiticinfections |