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The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820072/ https://www.ncbi.nlm.nih.gov/pubmed/24152755 http://dx.doi.org/10.3390/nu5104250 |
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author | Comino, Isabel de Lourdes Moreno, María Real, Ana Rodríguez-Herrera, Alfonso Barro, Francisco Sousa, Carolina |
author_facet | Comino, Isabel de Lourdes Moreno, María Real, Ana Rodríguez-Herrera, Alfonso Barro, Francisco Sousa, Carolina |
author_sort | Comino, Isabel |
collection | PubMed |
description | A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition. |
format | Online Article Text |
id | pubmed-3820072 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-38200722013-11-09 The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients Comino, Isabel de Lourdes Moreno, María Real, Ana Rodríguez-Herrera, Alfonso Barro, Francisco Sousa, Carolina Nutrients Review A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition. MDPI 2013-10-23 /pmc/articles/PMC3820072/ /pubmed/24152755 http://dx.doi.org/10.3390/nu5104250 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Comino, Isabel de Lourdes Moreno, María Real, Ana Rodríguez-Herrera, Alfonso Barro, Francisco Sousa, Carolina The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title | The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title_full | The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title_fullStr | The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title_full_unstemmed | The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title_short | The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients |
title_sort | gluten-free diet: testing alternative cereals tolerated by celiac patients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820072/ https://www.ncbi.nlm.nih.gov/pubmed/24152755 http://dx.doi.org/10.3390/nu5104250 |
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