Cargando…

The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the...

Descripción completa

Detalles Bibliográficos
Autores principales: Comino, Isabel, de Lourdes Moreno, María, Real, Ana, Rodríguez-Herrera, Alfonso, Barro, Francisco, Sousa, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820072/
https://www.ncbi.nlm.nih.gov/pubmed/24152755
http://dx.doi.org/10.3390/nu5104250
_version_ 1782290084625645568
author Comino, Isabel
de Lourdes Moreno, María
Real, Ana
Rodríguez-Herrera, Alfonso
Barro, Francisco
Sousa, Carolina
author_facet Comino, Isabel
de Lourdes Moreno, María
Real, Ana
Rodríguez-Herrera, Alfonso
Barro, Francisco
Sousa, Carolina
author_sort Comino, Isabel
collection PubMed
description A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition.
format Online
Article
Text
id pubmed-3820072
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-38200722013-11-09 The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients Comino, Isabel de Lourdes Moreno, María Real, Ana Rodríguez-Herrera, Alfonso Barro, Francisco Sousa, Carolina Nutrients Review A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition. MDPI 2013-10-23 /pmc/articles/PMC3820072/ /pubmed/24152755 http://dx.doi.org/10.3390/nu5104250 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Comino, Isabel
de Lourdes Moreno, María
Real, Ana
Rodríguez-Herrera, Alfonso
Barro, Francisco
Sousa, Carolina
The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title_full The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title_fullStr The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title_full_unstemmed The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title_short The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients
title_sort gluten-free diet: testing alternative cereals tolerated by celiac patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820072/
https://www.ncbi.nlm.nih.gov/pubmed/24152755
http://dx.doi.org/10.3390/nu5104250
work_keys_str_mv AT cominoisabel theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT delourdesmorenomaria theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT realana theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT rodriguezherreraalfonso theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT barrofrancisco theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT sousacarolina theglutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT cominoisabel glutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT delourdesmorenomaria glutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT realana glutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT rodriguezherreraalfonso glutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT barrofrancisco glutenfreediettestingalternativecerealstoleratedbyceliacpatients
AT sousacarolina glutenfreediettestingalternativecerealstoleratedbyceliacpatients