Cargando…

The Endocannabinoid System, Cannabinoids, and Pain

The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily b...

Descripción completa

Detalles Bibliográficos
Autores principales: Fine, Perry G., Rosenfeld, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/
https://www.ncbi.nlm.nih.gov/pubmed/24228165
http://dx.doi.org/10.5041/RMMJ.10129
_version_ 1782290115713826816
author Fine, Perry G.
Rosenfeld, Mark J.
author_facet Fine, Perry G.
Rosenfeld, Mark J.
author_sort Fine, Perry G.
collection PubMed
description The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB(1) receptors) and in the periphery (primarily but not exclusively CB(2) receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods, have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking), as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain.
format Online
Article
Text
id pubmed-3820295
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Rambam Health Care Campus
record_format MEDLINE/PubMed
spelling pubmed-38202952013-11-13 The Endocannabinoid System, Cannabinoids, and Pain Fine, Perry G. Rosenfeld, Mark J. Rambam Maimonides Med J Special Issue on Pain The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not exclusively CB(1) receptors) and in the periphery (primarily but not exclusively CB(2) receptors) are only partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids (phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods, have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking), as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide the reader with the foundational basic and clinical science linking the endocannabinoid system and the phytocannabinoids with their potentially therapeutic role in the management of chronic pain. Rambam Health Care Campus 2013-10-29 /pmc/articles/PMC3820295/ /pubmed/24228165 http://dx.doi.org/10.5041/RMMJ.10129 Text en © 2013 Fine and Rosenfeld. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue on Pain
Fine, Perry G.
Rosenfeld, Mark J.
The Endocannabinoid System, Cannabinoids, and Pain
title The Endocannabinoid System, Cannabinoids, and Pain
title_full The Endocannabinoid System, Cannabinoids, and Pain
title_fullStr The Endocannabinoid System, Cannabinoids, and Pain
title_full_unstemmed The Endocannabinoid System, Cannabinoids, and Pain
title_short The Endocannabinoid System, Cannabinoids, and Pain
title_sort endocannabinoid system, cannabinoids, and pain
topic Special Issue on Pain
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/
https://www.ncbi.nlm.nih.gov/pubmed/24228165
http://dx.doi.org/10.5041/RMMJ.10129
work_keys_str_mv AT fineperryg theendocannabinoidsystemcannabinoidsandpain
AT rosenfeldmarkj theendocannabinoidsystemcannabinoidsandpain
AT fineperryg endocannabinoidsystemcannabinoidsandpain
AT rosenfeldmarkj endocannabinoidsystemcannabinoidsandpain