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Stress in Obesity and Associated Metabolic and Cardiovascular Disorders

Obesity has significant implications for healthcare, since it is a major risk factor for both type 2 diabetes and the metabolic syndrome. This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. It is associated with high atherosclerotic c...

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Detalles Bibliográficos
Autor principal: Holvoet, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820434/
https://www.ncbi.nlm.nih.gov/pubmed/24278677
http://dx.doi.org/10.6064/2012/205027
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author Holvoet, Paul
author_facet Holvoet, Paul
author_sort Holvoet, Paul
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description Obesity has significant implications for healthcare, since it is a major risk factor for both type 2 diabetes and the metabolic syndrome. This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. It is associated with high atherosclerotic cardiovascular risk, which can only partially be explained by its components. Therefore, to explain how obesity contributes to the development of metabolic and cardiovascular disorders, more and better insight is required into the effects of personal and environmental stress on disease processes. In this paper, we show that obesity is a chronic inflammatory disease, which has many molecular mechanisms in common with atherosclerosis. Furthermore, we focus on the role of oxidative stress associated with obesity in the development of the metabolic syndrome. We discuss how several stress conditions are related to inflammation and oxidative stress in association with obesity and its complications. We also emphasize the relation between stress conditions and the deregulation of epigenetic control mechanisms by means of microRNAs and show how this impairment further contributes to the development of obesity, closing the vicious circle. Finally, we discuss the limitations of current anti-inflammation and antioxidant therapy to treat obesity.
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spelling pubmed-38204342013-11-25 Stress in Obesity and Associated Metabolic and Cardiovascular Disorders Holvoet, Paul Scientifica (Cairo) Review Article Obesity has significant implications for healthcare, since it is a major risk factor for both type 2 diabetes and the metabolic syndrome. This syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance. It is associated with high atherosclerotic cardiovascular risk, which can only partially be explained by its components. Therefore, to explain how obesity contributes to the development of metabolic and cardiovascular disorders, more and better insight is required into the effects of personal and environmental stress on disease processes. In this paper, we show that obesity is a chronic inflammatory disease, which has many molecular mechanisms in common with atherosclerosis. Furthermore, we focus on the role of oxidative stress associated with obesity in the development of the metabolic syndrome. We discuss how several stress conditions are related to inflammation and oxidative stress in association with obesity and its complications. We also emphasize the relation between stress conditions and the deregulation of epigenetic control mechanisms by means of microRNAs and show how this impairment further contributes to the development of obesity, closing the vicious circle. Finally, we discuss the limitations of current anti-inflammation and antioxidant therapy to treat obesity. Hindawi Publishing Corporation 2012 2012-12-31 /pmc/articles/PMC3820434/ /pubmed/24278677 http://dx.doi.org/10.6064/2012/205027 Text en Copyright © 2012 Paul Holvoet. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Holvoet, Paul
Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title_full Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title_fullStr Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title_full_unstemmed Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title_short Stress in Obesity and Associated Metabolic and Cardiovascular Disorders
title_sort stress in obesity and associated metabolic and cardiovascular disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820434/
https://www.ncbi.nlm.nih.gov/pubmed/24278677
http://dx.doi.org/10.6064/2012/205027
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