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Established and Emerging Approaches for the Management of Dyslipidaemia
The key role of dyslipidaemia in determining cardiovascular disease (CVD) has been proved beyond reasonable doubt, and therefore several dietary and pharmacological approaches have been developed. The discovery of statins has provided a very effective approach in reducing cardiovascular risk as docu...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820450/ https://www.ncbi.nlm.nih.gov/pubmed/24278703 http://dx.doi.org/10.6064/2012/482423 |
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author | Norata, Giuseppe Danilo |
author_facet | Norata, Giuseppe Danilo |
author_sort | Norata, Giuseppe Danilo |
collection | PubMed |
description | The key role of dyslipidaemia in determining cardiovascular disease (CVD) has been proved beyond reasonable doubt, and therefore several dietary and pharmacological approaches have been developed. The discovery of statins has provided a very effective approach in reducing cardiovascular risk as documented by the results obtained in clinical trials and in clinical practice. The current efficacy of statins or other drugs, however, comes short of providing the benefit that could derive from a further reduction of LDL cholesterol (LDL-C) in high-risk and very high risk patients. Furthermore, experimental data clearly suggest that other lipoprotein classes beyond LDL play important roles in determining cardiovascular risk. For these reasons a number of new potential drugs are under development in this area. Aim of this review is to discuss the available and the future pharmacological strategies for the management of dyslipidemia. |
format | Online Article Text |
id | pubmed-3820450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38204502013-11-25 Established and Emerging Approaches for the Management of Dyslipidaemia Norata, Giuseppe Danilo Scientifica (Cairo) Review Article The key role of dyslipidaemia in determining cardiovascular disease (CVD) has been proved beyond reasonable doubt, and therefore several dietary and pharmacological approaches have been developed. The discovery of statins has provided a very effective approach in reducing cardiovascular risk as documented by the results obtained in clinical trials and in clinical practice. The current efficacy of statins or other drugs, however, comes short of providing the benefit that could derive from a further reduction of LDL cholesterol (LDL-C) in high-risk and very high risk patients. Furthermore, experimental data clearly suggest that other lipoprotein classes beyond LDL play important roles in determining cardiovascular risk. For these reasons a number of new potential drugs are under development in this area. Aim of this review is to discuss the available and the future pharmacological strategies for the management of dyslipidemia. Hindawi Publishing Corporation 2012 2012-09-10 /pmc/articles/PMC3820450/ /pubmed/24278703 http://dx.doi.org/10.6064/2012/482423 Text en Copyright © 2012 Giuseppe Danilo Norata. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Norata, Giuseppe Danilo Established and Emerging Approaches for the Management of Dyslipidaemia |
title | Established and Emerging Approaches for the Management of Dyslipidaemia |
title_full | Established and Emerging Approaches for the Management of Dyslipidaemia |
title_fullStr | Established and Emerging Approaches for the Management of Dyslipidaemia |
title_full_unstemmed | Established and Emerging Approaches for the Management of Dyslipidaemia |
title_short | Established and Emerging Approaches for the Management of Dyslipidaemia |
title_sort | established and emerging approaches for the management of dyslipidaemia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820450/ https://www.ncbi.nlm.nih.gov/pubmed/24278703 http://dx.doi.org/10.6064/2012/482423 |
work_keys_str_mv | AT noratagiuseppedanilo establishedandemergingapproachesforthemanagementofdyslipidaemia |