Clinical Pharmacology in Old Persons

The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities and are treated with a large number of medici...

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Detalles Bibliográficos
Autores principales: Jansen, Paul A. F., Brouwers, Jacobus R. B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820465/
https://www.ncbi.nlm.nih.gov/pubmed/24278735
http://dx.doi.org/10.6064/2012/723678
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author Jansen, Paul A. F.
Brouwers, Jacobus R. B. J.
author_facet Jansen, Paul A. F.
Brouwers, Jacobus R. B. J.
author_sort Jansen, Paul A. F.
collection PubMed
description The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities and are treated with a large number of medicines. In advanced age, the pharmacokinetics and pharmacodynamics of many drugs are altered. In addition, pharmacotherapy may be complicated by difficulties with obtaining drugs or adherence and persistence with drug regimens. Safe and effective pharmacotherapy remains one of the greatest challenges in geriatric medicine. In this paper, the main principles of geriatric pharmacology are presented.
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spelling pubmed-38204652013-11-25 Clinical Pharmacology in Old Persons Jansen, Paul A. F. Brouwers, Jacobus R. B. J. Scientifica (Cairo) Review Article The epidemiological transition, with a rapid increase in the proportion in the global population aged over 65 years from 11% in 2010 to 22% in 2050 and 32% in 2100, represents a challenge for public health. More and more old persons have multimorbidities and are treated with a large number of medicines. In advanced age, the pharmacokinetics and pharmacodynamics of many drugs are altered. In addition, pharmacotherapy may be complicated by difficulties with obtaining drugs or adherence and persistence with drug regimens. Safe and effective pharmacotherapy remains one of the greatest challenges in geriatric medicine. In this paper, the main principles of geriatric pharmacology are presented. Hindawi Publishing Corporation 2012 2012-07-28 /pmc/articles/PMC3820465/ /pubmed/24278735 http://dx.doi.org/10.6064/2012/723678 Text en Copyright © 2012 P. A. F. Jansen and J. R. B. J. Brouwers. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jansen, Paul A. F.
Brouwers, Jacobus R. B. J.
Clinical Pharmacology in Old Persons
title Clinical Pharmacology in Old Persons
title_full Clinical Pharmacology in Old Persons
title_fullStr Clinical Pharmacology in Old Persons
title_full_unstemmed Clinical Pharmacology in Old Persons
title_short Clinical Pharmacology in Old Persons
title_sort clinical pharmacology in old persons
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820465/
https://www.ncbi.nlm.nih.gov/pubmed/24278735
http://dx.doi.org/10.6064/2012/723678
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