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Tissue Factor Structure and Function

Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting...

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Detalles Bibliográficos
Autor principal: Butenas, Saulius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820524/
https://www.ncbi.nlm.nih.gov/pubmed/24278763
http://dx.doi.org/10.6064/2012/964862
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author Butenas, Saulius
author_facet Butenas, Saulius
author_sort Butenas, Saulius
collection PubMed
description Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting complex initiates a series of enzymatic reactions leading to clot formation and vascular sealing. Many cells, both healthy, and tumor cells, produce detectable amounts of TF, especially when they are stimulated by various agents. Despite the relative simplicity and small size of TF, there are numerous contradictory reports about the synthesis and presentation of TF on blood cells and circulation in normal blood either on microparticles or as a soluble protein. Another subject of controversy is related to the structure/function of TF. It has been almost commonly accepted that cell-surface-associated TF has low (if any) activity, that is, is “encrypted” and requires specific conditions/reagents to become active, that is, “decrypted.” However there is a lack of agreement related to the mechanism and processes leading to alterations in TF function. In this paper TF structure, presentation, and function, and controversies concerning these features are discussed.
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spelling pubmed-38205242013-11-25 Tissue Factor Structure and Function Butenas, Saulius Scientifica (Cairo) Review Article Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting complex initiates a series of enzymatic reactions leading to clot formation and vascular sealing. Many cells, both healthy, and tumor cells, produce detectable amounts of TF, especially when they are stimulated by various agents. Despite the relative simplicity and small size of TF, there are numerous contradictory reports about the synthesis and presentation of TF on blood cells and circulation in normal blood either on microparticles or as a soluble protein. Another subject of controversy is related to the structure/function of TF. It has been almost commonly accepted that cell-surface-associated TF has low (if any) activity, that is, is “encrypted” and requires specific conditions/reagents to become active, that is, “decrypted.” However there is a lack of agreement related to the mechanism and processes leading to alterations in TF function. In this paper TF structure, presentation, and function, and controversies concerning these features are discussed. Hindawi Publishing Corporation 2012 2012-12-26 /pmc/articles/PMC3820524/ /pubmed/24278763 http://dx.doi.org/10.6064/2012/964862 Text en Copyright © 2012 Saulius Butenas. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Butenas, Saulius
Tissue Factor Structure and Function
title Tissue Factor Structure and Function
title_full Tissue Factor Structure and Function
title_fullStr Tissue Factor Structure and Function
title_full_unstemmed Tissue Factor Structure and Function
title_short Tissue Factor Structure and Function
title_sort tissue factor structure and function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820524/
https://www.ncbi.nlm.nih.gov/pubmed/24278763
http://dx.doi.org/10.6064/2012/964862
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