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Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis

An epithelial duct is a well-defined multicellular structure composed of tightly packed cells separating and protecting body compartments that are used for enzyme secretion and its transport across the internal. The structural and functional integrity (homeostasis) of such ducts is vital in carrying...

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Autor principal: Rejniak, Katarzyna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820568/
https://www.ncbi.nlm.nih.gov/pubmed/24278670
http://dx.doi.org/10.6064/2012/132978
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author Rejniak, Katarzyna A.
author_facet Rejniak, Katarzyna A.
author_sort Rejniak, Katarzyna A.
collection PubMed
description An epithelial duct is a well-defined multicellular structure composed of tightly packed cells separating and protecting body compartments that are used for enzyme secretion and its transport across the internal. The structural and functional integrity (homeostasis) of such ducts is vital in carrying many life functions (breathing, lactation, production of hormones). However, the processes involved in maintaining the homeostatic balance are not yet fully understood. On the other hand, the loss of epithelial tissue architecture, such as filled lumens or ductal disorganization, are among the first symptoms of the emerging epithelial tumors (carcinomas). Using the previously developed biomechanical model of epithelial ducts: IBCell, we investigated how different signals and mechanical stimuli imposed on individual epithelial cells can impact the homeostatic (im)balance and integrity of the whole epithelial tissue. We provide a link between erroneous responses of individual epithelial cells to specific signals and the emerging ductal morphologies characteristic for preinvasive cancers observed in pathology specimens, or characteristic for multicellular structures arising from mutated cells cultured in vitro. We summarize our finding in terms of altered properties of epithelial cell polarization, and discuss the relative importance of various polarization signals on the formation of tumor-like multicellular structures.
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spelling pubmed-38205682013-11-25 Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis Rejniak, Katarzyna A. Scientifica (Cairo) Research Article An epithelial duct is a well-defined multicellular structure composed of tightly packed cells separating and protecting body compartments that are used for enzyme secretion and its transport across the internal. The structural and functional integrity (homeostasis) of such ducts is vital in carrying many life functions (breathing, lactation, production of hormones). However, the processes involved in maintaining the homeostatic balance are not yet fully understood. On the other hand, the loss of epithelial tissue architecture, such as filled lumens or ductal disorganization, are among the first symptoms of the emerging epithelial tumors (carcinomas). Using the previously developed biomechanical model of epithelial ducts: IBCell, we investigated how different signals and mechanical stimuli imposed on individual epithelial cells can impact the homeostatic (im)balance and integrity of the whole epithelial tissue. We provide a link between erroneous responses of individual epithelial cells to specific signals and the emerging ductal morphologies characteristic for preinvasive cancers observed in pathology specimens, or characteristic for multicellular structures arising from mutated cells cultured in vitro. We summarize our finding in terms of altered properties of epithelial cell polarization, and discuss the relative importance of various polarization signals on the formation of tumor-like multicellular structures. Hindawi Publishing Corporation 2012 2012-07-12 /pmc/articles/PMC3820568/ /pubmed/24278670 http://dx.doi.org/10.6064/2012/132978 Text en Copyright © 2012 Katarzyna A. Rejniak. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rejniak, Katarzyna A.
Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title_full Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title_fullStr Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title_full_unstemmed Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title_short Homeostatic Imbalance in Epithelial Ducts and Its Role in Carcinogenesis
title_sort homeostatic imbalance in epithelial ducts and its role in carcinogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820568/
https://www.ncbi.nlm.nih.gov/pubmed/24278670
http://dx.doi.org/10.6064/2012/132978
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