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Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking
OBJECTIVE: The aims of this study were to investigate the association between the +781C/T polymorphism of interleukin-8 (IL-8) and atherosclerotic cerebral infarction and the interaction between the +781C/T polymorphism and smoking or drinking in cerebral infarction in the Han Chinese population. ME...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820576/ https://www.ncbi.nlm.nih.gov/pubmed/24244661 http://dx.doi.org/10.1371/journal.pone.0080246 |
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author | Luo, Shijian Wang, Feng Li, Zhendong Deng, Jinfeng |
author_facet | Luo, Shijian Wang, Feng Li, Zhendong Deng, Jinfeng |
author_sort | Luo, Shijian |
collection | PubMed |
description | OBJECTIVE: The aims of this study were to investigate the association between the +781C/T polymorphism of interleukin-8 (IL-8) and atherosclerotic cerebral infarction and the interaction between the +781C/T polymorphism and smoking or drinking in cerebral infarction in the Han Chinese population. METHODS: We investigated the +781C/T polymorphism of IL-8 in 308 consecutive Han Chinese patients who were diagnosed with atherosclerotic cerebral infarction and in 294 age- and gender-matched healthy control subjects. The patients were classified using the Oxfordshire Community Stroke Project (OCSP) classification. The patients and subjects’ histories of smoking and drinking were recorded, and atherosclerosis (AS) of the internal carotid artery (ICA) was evaluated in the patients. The +781C/T polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: The +781C/T polymorphism and allele frequencies were not significantly different between the patients and controls and were not significantly associated with the OCSP classifications. We found that the 781C allele was significantly associated with AS of the ICA in the patients (p = 0.017), and the CT genotype was more prevalent in patients without AS of the ICA (p = 0.035). No interactions were observed between the +781C/T polymorphism and smoking or drinking. CONCLUSION: Our results demonstrated that the +781C/T polymorphism of IL-8 did not play a role and had no interaction with smoking or drinking in the occurrence of cerebral infarction in the Han Chinese population. However, the C allele and the CT genotype might be associated with AS of the ICA in patients with ischemic stroke. |
format | Online Article Text |
id | pubmed-3820576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38205762013-11-15 Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking Luo, Shijian Wang, Feng Li, Zhendong Deng, Jinfeng PLoS One Research Article OBJECTIVE: The aims of this study were to investigate the association between the +781C/T polymorphism of interleukin-8 (IL-8) and atherosclerotic cerebral infarction and the interaction between the +781C/T polymorphism and smoking or drinking in cerebral infarction in the Han Chinese population. METHODS: We investigated the +781C/T polymorphism of IL-8 in 308 consecutive Han Chinese patients who were diagnosed with atherosclerotic cerebral infarction and in 294 age- and gender-matched healthy control subjects. The patients were classified using the Oxfordshire Community Stroke Project (OCSP) classification. The patients and subjects’ histories of smoking and drinking were recorded, and atherosclerosis (AS) of the internal carotid artery (ICA) was evaluated in the patients. The +781C/T polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: The +781C/T polymorphism and allele frequencies were not significantly different between the patients and controls and were not significantly associated with the OCSP classifications. We found that the 781C allele was significantly associated with AS of the ICA in the patients (p = 0.017), and the CT genotype was more prevalent in patients without AS of the ICA (p = 0.035). No interactions were observed between the +781C/T polymorphism and smoking or drinking. CONCLUSION: Our results demonstrated that the +781C/T polymorphism of IL-8 did not play a role and had no interaction with smoking or drinking in the occurrence of cerebral infarction in the Han Chinese population. However, the C allele and the CT genotype might be associated with AS of the ICA in patients with ischemic stroke. Public Library of Science 2013-11-07 /pmc/articles/PMC3820576/ /pubmed/24244661 http://dx.doi.org/10.1371/journal.pone.0080246 Text en © 2013 Luo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Luo, Shijian Wang, Feng Li, Zhendong Deng, Jinfeng Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title | Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title_full | Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title_fullStr | Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title_full_unstemmed | Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title_short | Effect of the +781C/T Polymorphism in the Interleukin-8 Gene on Atherosclerotic Cerebral Infarction, and Its Interaction with Smoking and Drinking |
title_sort | effect of the +781c/t polymorphism in the interleukin-8 gene on atherosclerotic cerebral infarction, and its interaction with smoking and drinking |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820576/ https://www.ncbi.nlm.nih.gov/pubmed/24244661 http://dx.doi.org/10.1371/journal.pone.0080246 |
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