A High-Throughput Screen against Pantothenate Synthetase (PanC) Identifies 3-Biphenyl-4-Cyanopyrrole-2-Carboxylic Acids as a New Class of Inhibitor with Activity against Mycobacterium tuberculosis

The enzyme pantothenate synthetase, PanC, is an attractive drug target in Mycobacterium tuberculosis. It is essential for the in vitro growth of M. tuberculosis and for survival of the bacteria in the mouse model of infection. PanC is absent from mammals. We developed an enzyme-based assay to identi...

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Detalles Bibliográficos
Autores principales: Kumar, Anuradha, Casey, Allen, Odingo, Joshua, Kesicki, Edward A., Abrahams, Garth, Vieth, Michal, Masquelin, Thierry, Mizrahi, Valerie, Hipskind, Philip A., Sherman, David R., Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820577/
https://www.ncbi.nlm.nih.gov/pubmed/24244263
http://dx.doi.org/10.1371/journal.pone.0072786

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