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In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy

Until now, biochemical parameter for diagnosis of intrahepatic cholestasis of pregnancy (ICP) mostly used is the rise of total serum bile acids (TSBA) above the upper normal limit of 11 μM. However, differential diagnosis is very difficult since overlapped values calculated on bile acids determinati...

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Autores principales: Martinefski, Manuela, Contin, Mario, Lucangioli, Silvia, Di Carlo, Maria Beatriz, Tripodi, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820586/
https://www.ncbi.nlm.nih.gov/pubmed/24278705
http://dx.doi.org/10.6064/2012/496489
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author Martinefski, Manuela
Contin, Mario
Lucangioli, Silvia
Di Carlo, Maria Beatriz
Tripodi, Valeria
author_facet Martinefski, Manuela
Contin, Mario
Lucangioli, Silvia
Di Carlo, Maria Beatriz
Tripodi, Valeria
author_sort Martinefski, Manuela
collection PubMed
description Until now, biochemical parameter for diagnosis of intrahepatic cholestasis of pregnancy (ICP) mostly used is the rise of total serum bile acids (TSBA) above the upper normal limit of 11 μM. However, differential diagnosis is very difficult since overlapped values calculated on bile acids determinations, are observed in different conditions of pregnancy including the benign condition of pruritus gravidarum. The aim of this work was to determine the better markers in ICP for a precise diagnosis together with parameters associated with severity of symptoms and treatment evaluation. Serum bile acid profiles were evaluated using capillary electrophoresis in 38 healthy pregnant women and 32 ICP patients and it was calculated the sensitivity, specificity, accuracy, predictive values and the relationships of certain individual bile acids in pregnant women in order to replace TSBA determinations. The evaluation of the results shows that LCA and UDCA/LCA ratio provided information for a more complete and accurate diagnosis and evaluation of ICP than calculation of solely TSBA levels in pregnant women.
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spelling pubmed-38205862013-11-25 In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy Martinefski, Manuela Contin, Mario Lucangioli, Silvia Di Carlo, Maria Beatriz Tripodi, Valeria Scientifica (Cairo) Clinical Study Until now, biochemical parameter for diagnosis of intrahepatic cholestasis of pregnancy (ICP) mostly used is the rise of total serum bile acids (TSBA) above the upper normal limit of 11 μM. However, differential diagnosis is very difficult since overlapped values calculated on bile acids determinations, are observed in different conditions of pregnancy including the benign condition of pruritus gravidarum. The aim of this work was to determine the better markers in ICP for a precise diagnosis together with parameters associated with severity of symptoms and treatment evaluation. Serum bile acid profiles were evaluated using capillary electrophoresis in 38 healthy pregnant women and 32 ICP patients and it was calculated the sensitivity, specificity, accuracy, predictive values and the relationships of certain individual bile acids in pregnant women in order to replace TSBA determinations. The evaluation of the results shows that LCA and UDCA/LCA ratio provided information for a more complete and accurate diagnosis and evaluation of ICP than calculation of solely TSBA levels in pregnant women. Hindawi Publishing Corporation 2012 2012-08-01 /pmc/articles/PMC3820586/ /pubmed/24278705 http://dx.doi.org/10.6064/2012/496489 Text en Copyright © 2012 Manuela Martinefski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Martinefski, Manuela
Contin, Mario
Lucangioli, Silvia
Di Carlo, Maria Beatriz
Tripodi, Valeria
In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title_full In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title_fullStr In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title_full_unstemmed In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title_short In Search of an Accurate Evaluation of Intrahepatic Cholestasis of Pregnancy
title_sort in search of an accurate evaluation of intrahepatic cholestasis of pregnancy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820586/
https://www.ncbi.nlm.nih.gov/pubmed/24278705
http://dx.doi.org/10.6064/2012/496489
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