MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters

A variable proportion of patients with generalized myasthenia gravis (MG) have autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin, released from the motor nerve, interacts with low density lipoprotein receptor-related protein-4 (LRP4), which then binds to MuSK; MuSK i...

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Detalles Bibliográficos
Autores principales: Koneczny, Inga, Cossins, Judith, Waters, Patrick, Beeson, David, Vincent, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820634/
https://www.ncbi.nlm.nih.gov/pubmed/24244707
http://dx.doi.org/10.1371/journal.pone.0080695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820634/
https://www.ncbi.nlm.nih.gov/pubmed/24244707
http://dx.doi.org/10.1371/journal.pone.0080695

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