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Replication-Dependent and Transcription-Dependent Mechanisms of DNA Double-Strand Break Induction by the Topoisomerase 2-Targeting Drug Etoposide

Etoposide is a DNA topoisomerase 2-targeting drug widely used for the treatment of cancer. The cytoxicity of etoposide correlates with the generation of DNA double-strand breaks (DSBs), but the mechanism of how it induces DSBs in cells is still poorly understood. Catalytically, etoposide inhibits th...

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Detalles Bibliográficos
Autores principales:	Tammaro, Margaret, Barr, Peri, Ricci, Brett, Yan, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820710/ https://www.ncbi.nlm.nih.gov/pubmed/24244448 http://dx.doi.org/10.1371/journal.pone.0079202

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