Turning Defense into Offense: Defensin Mimetics as Novel Antibiotics Targeting Lipid II

We have previously reported on the functional interaction of Lipid II with human alpha-defensins, a class of antimicrobial peptides. Lipid II is an essential precursor for bacterial cell wall biosynthesis and an ideal and validated target for natural antibiotic compounds. Using a combination of stru...

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Detalles Bibliográficos
Autores principales: Varney, Kristen M., Bonvin, Alexandre M. J. J., Pazgier, Marzena, Malin, Jakob, Yu, Wenbo, Ateh, Eugene, Oashi, Taiji, Lu, Wuyuan, Huang, Jing, Diepeveen-de Buin, Marlies, Bryant, Joseph, Breukink, Eefjan, MacKerell, Alexander D., de Leeuw, Erik P. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820767/
https://www.ncbi.nlm.nih.gov/pubmed/24244161
http://dx.doi.org/10.1371/journal.ppat.1003732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820767/
https://www.ncbi.nlm.nih.gov/pubmed/24244161
http://dx.doi.org/10.1371/journal.ppat.1003732

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