IL-17 cytokines in immunity and inflammation

Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflamm...

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Detalles Bibliográficos
Autores principales: Jin, Wei, Dong, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820987/
https://www.ncbi.nlm.nih.gov/pubmed/26038490
http://dx.doi.org/10.1038/emi.2013.58
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author Jin, Wei
Dong, Chen
author_facet Jin, Wei
Dong, Chen
author_sort Jin, Wei
collection PubMed
description Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.
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spelling pubmed-38209872013-11-09 IL-17 cytokines in immunity and inflammation Jin, Wei Dong, Chen Emerg Microbes Infect Review Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients. Nature Publishing Group 2013-09 2013-09-18 /pmc/articles/PMC3820987/ /pubmed/26038490 http://dx.doi.org/10.1038/emi.2013.58 Text en Copyright © 2013 Shanghai Shangyixun Cultural Communication Co., Ltd http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Review
Jin, Wei
Dong, Chen
IL-17 cytokines in immunity and inflammation
title IL-17 cytokines in immunity and inflammation
title_full IL-17 cytokines in immunity and inflammation
title_fullStr IL-17 cytokines in immunity and inflammation
title_full_unstemmed IL-17 cytokines in immunity and inflammation
title_short IL-17 cytokines in immunity and inflammation
title_sort il-17 cytokines in immunity and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820987/
https://www.ncbi.nlm.nih.gov/pubmed/26038490
http://dx.doi.org/10.1038/emi.2013.58
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