Tannic acid, a higher galloylated pentagalloylglucose, suppresses antigen-specific IgE production by inhibiting ɛ germline transcription induced by STAT6 activation()

Interleukin (IL)-4 is a critical stimulator that induces ɛ germline transcripts (ɛGT) for switch recombination to initiate immunoglobulin (Ig) E and is important in allergic disease pathogenesis. We found pentagalloylglucose (PGG) inhibited IL-4-induced ɛGT expression. PGG exerted its inhibitory fun...

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Detalles Bibliográficos
Autores principales: Kim, Yoon Hee, Yoshimoto, Miki, Nakayama, Kazuko, Tanino, Sousuke, Fujimura, Yoshinori, Yamada, Koji, Tachibana, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821021/
https://www.ncbi.nlm.nih.gov/pubmed/24251093
http://dx.doi.org/10.1016/j.fob.2013.07.008

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