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Specificity in the actions of the UBR1 ubiquitin ligase in the degradation of nuclear receptors()
The UBR1 ubiquitin ligase promotes degradation of proteins via the N-end rule and by another mechanism that detects a misfolded conformation. Although UBR1 was shown recently to act on protein kinases whose misfolding was promoted by inhibition of Hsp90, it was unknown whether this ubiquitin ligase...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821023/ https://www.ncbi.nlm.nih.gov/pubmed/24251101 http://dx.doi.org/10.1016/j.fob.2013.09.003 |