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Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues()

The tetrasaccharide heparan sulfate (HS) mimetic PG545, a clinical anti-cancer candidate, is an inhibitor of the HS-degrading enzyme heparanase. The kinetics of heparanase inhibition by PG545 and three structural analogues were investigated to understand their modes of inhibition. The cholestanol ag...

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Detalles Bibliográficos
Autores principales:	Hammond, Edward, Handley, Paul, Dredge, Keith, Bytheway, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821029/ https://www.ncbi.nlm.nih.gov/pubmed/24251094 http://dx.doi.org/10.1016/j.fob.2013.07.007

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