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Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation

AIM: Extracorporeal circulation (ECC) of blood during cardiopulmonary surgery has been shown to stimulate various pro-inflammatory molecules such as cytokines and chemokines. The biochemical oxidation/reduction pathways of a-lipoic acid suggest that it may have antioxidant properties. METHODS: In th...

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Autores principales: Uyar, Ihsan Sami, Akpinar, M Besir, Sahin, Veysel, Abdulhadi, Onal, Suleyman, Gonen, Ibak, Cihangir Uguz, Abdulhadi, Burma, Oktay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821094/
https://www.ncbi.nlm.nih.gov/pubmed/24240384
http://dx.doi.org/10.5830/CVJA-2013-067
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author Uyar, Ihsan Sami
Akpinar, M Besir
Sahin, Veysel
Abdulhadi,
Onal, Suleyman
Gonen, Ibak
Cihangir Uguz, Abdulhadi
Burma, Oktay
author_facet Uyar, Ihsan Sami
Akpinar, M Besir
Sahin, Veysel
Abdulhadi,
Onal, Suleyman
Gonen, Ibak
Cihangir Uguz, Abdulhadi
Burma, Oktay
author_sort Uyar, Ihsan Sami
collection PubMed
description AIM: Extracorporeal circulation (ECC) of blood during cardiopulmonary surgery has been shown to stimulate various pro-inflammatory molecules such as cytokines and chemokines. The biochemical oxidation/reduction pathways of a-lipoic acid suggest that it may have antioxidant properties. METHODS: In this study we aimed to evaluate only patients with coronary heart disease and those planned for coronary artery bypass graft operation. Blood samples were obtained from the patients before the operation (P1) and one (P2), four (P3), 24 (P4) and 48 hours (P5) after administration of a-lipoic acid (LA). The patients were divided into two groups, control and LA treatment group. Levels of interleukin-6 (IL-6) and -8 (IL-8), complement 3 (C3) and 4 (C4), anti-streptolysin (ASO), C-reactive protein (CRP) and haptoglobin were assessed in the blood samples. RESULTS: Cytokine IL-6 and IL-8 levels were significantly higher after surgery. Compared with the control groups, LA significantly decreased IL-6 and IL-8 levels in a time-dependent manner. CRP levels did not show significant variation in the first three time periods. CRP levels were higher after surgery, especially in the later periods. These results demonstrate that CRP formation depends on cytokine release. C3 and C4 levels were significantly higher after surgery than in the pre-operative period. LA treatment decreased C3 and C4 levels. Therefore, LA administration may be useful for the treatment of diseases and processes where excessive cytokine release could cause oxidative damage. CONCLUSIONS: Our findings suggest a possible benefit of using LA during cardiac surgery to reduce cytokine levels.
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spelling pubmed-38210942013-11-18 Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation Uyar, Ihsan Sami Akpinar, M Besir Sahin, Veysel Abdulhadi, Onal, Suleyman Gonen, Ibak Cihangir Uguz, Abdulhadi Burma, Oktay Cardiovasc J Afr Cardiovascular Topics AIM: Extracorporeal circulation (ECC) of blood during cardiopulmonary surgery has been shown to stimulate various pro-inflammatory molecules such as cytokines and chemokines. The biochemical oxidation/reduction pathways of a-lipoic acid suggest that it may have antioxidant properties. METHODS: In this study we aimed to evaluate only patients with coronary heart disease and those planned for coronary artery bypass graft operation. Blood samples were obtained from the patients before the operation (P1) and one (P2), four (P3), 24 (P4) and 48 hours (P5) after administration of a-lipoic acid (LA). The patients were divided into two groups, control and LA treatment group. Levels of interleukin-6 (IL-6) and -8 (IL-8), complement 3 (C3) and 4 (C4), anti-streptolysin (ASO), C-reactive protein (CRP) and haptoglobin were assessed in the blood samples. RESULTS: Cytokine IL-6 and IL-8 levels were significantly higher after surgery. Compared with the control groups, LA significantly decreased IL-6 and IL-8 levels in a time-dependent manner. CRP levels did not show significant variation in the first three time periods. CRP levels were higher after surgery, especially in the later periods. These results demonstrate that CRP formation depends on cytokine release. C3 and C4 levels were significantly higher after surgery than in the pre-operative period. LA treatment decreased C3 and C4 levels. Therefore, LA administration may be useful for the treatment of diseases and processes where excessive cytokine release could cause oxidative damage. CONCLUSIONS: Our findings suggest a possible benefit of using LA during cardiac surgery to reduce cytokine levels. Clinics Cardive Publishing 2013-10 /pmc/articles/PMC3821094/ /pubmed/24240384 http://dx.doi.org/10.5830/CVJA-2013-067 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Uyar, Ihsan Sami
Akpinar, M Besir
Sahin, Veysel
Abdulhadi,
Onal, Suleyman
Gonen, Ibak
Cihangir Uguz, Abdulhadi
Burma, Oktay
Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title_full Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title_fullStr Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title_full_unstemmed Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title_short Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
title_sort alpha lipoic acid attenuates inflammatory response during extracorporeal circulation
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821094/
https://www.ncbi.nlm.nih.gov/pubmed/24240384
http://dx.doi.org/10.5830/CVJA-2013-067
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