TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu

Adoptive transfer of T cells gene-engineered with antigen-specific T cell receptors (TCRs) has proven its feasibility and therapeutic potential in the treatment of malignant tumors. To ensure further clinical development of TCR gene therapy, it is necessary to target immunogenic epitopes that are re...

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Detalles Bibliográficos
Autores principales: Kunert, Andre, Straetemans, Trudy, Govers, Coen, Lamers, Cor, Mathijssen, Ron, Sleijfer, Stefan, Debets, Reno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821161/
https://www.ncbi.nlm.nih.gov/pubmed/24265631
http://dx.doi.org/10.3389/fimmu.2013.00363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821161/
https://www.ncbi.nlm.nih.gov/pubmed/24265631
http://dx.doi.org/10.3389/fimmu.2013.00363

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