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Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshava...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821254/ https://www.ncbi.nlm.nih.gov/pubmed/24250134 http://dx.doi.org/10.4103/0974-8520.119686 |
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author | Kumar, Sunil Singh, Gajendra Reddy, K. R. C. |
author_facet | Kumar, Sunil Singh, Gajendra Reddy, K. R. C. |
author_sort | Kumar, Sunil |
collection | PubMed |
description | Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day “0” to day “18” of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls. |
format | Online Article Text |
id | pubmed-3821254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-38212542013-11-18 Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo Kumar, Sunil Singh, Gajendra Reddy, K. R. C. Ayu Pharmacological Study Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day “0” to day “18” of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3821254/ /pubmed/24250134 http://dx.doi.org/10.4103/0974-8520.119686 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Pharmacological Study Kumar, Sunil Singh, Gajendra Reddy, K. R. C. Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title | Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title_full | Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title_fullStr | Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title_full_unstemmed | Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title_short | Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
title_sort | effect of drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo |
topic | Pharmacological Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821254/ https://www.ncbi.nlm.nih.gov/pubmed/24250134 http://dx.doi.org/10.4103/0974-8520.119686 |
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