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Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo

Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshava...

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Autores principales: Kumar, Sunil, Singh, Gajendra, Reddy, K. R. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821254/
https://www.ncbi.nlm.nih.gov/pubmed/24250134
http://dx.doi.org/10.4103/0974-8520.119686
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author Kumar, Sunil
Singh, Gajendra
Reddy, K. R. C.
author_facet Kumar, Sunil
Singh, Gajendra
Reddy, K. R. C.
author_sort Kumar, Sunil
collection PubMed
description Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day “0” to day “18” of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls.
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spelling pubmed-38212542013-11-18 Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo Kumar, Sunil Singh, Gajendra Reddy, K. R. C. Ayu Pharmacological Study Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day “0” to day “18” of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3821254/ /pubmed/24250134 http://dx.doi.org/10.4103/0974-8520.119686 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmacological Study
Kumar, Sunil
Singh, Gajendra
Reddy, K. R. C.
Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title_full Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title_fullStr Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title_full_unstemmed Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title_short Effect of Drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
title_sort effect of drakshavaleha in cyclophosphamide induced weight loss and reduction in crown-rump length in developing mice embryo
topic Pharmacological Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821254/
https://www.ncbi.nlm.nih.gov/pubmed/24250134
http://dx.doi.org/10.4103/0974-8520.119686
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