MicroRNAs in prostate cancer

MicroRNAs (miRNAs) are made up of −22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic...

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Detalles Bibliográficos
Autores principales: Kim, Won Tae, Kim, Wun-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asian Pacific Prostate Society (APPS) 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821523/
https://www.ncbi.nlm.nih.gov/pubmed/24223395
http://dx.doi.org/10.12954/PI.12011
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author Kim, Won Tae
Kim, Wun-Jae
author_facet Kim, Won Tae
Kim, Wun-Jae
author_sort Kim, Won Tae
collection PubMed
description MicroRNAs (miRNAs) are made up of −22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic markers for various cancers. Also, alterations of miRNAs in cancer tissues have been associated with clinicopathological parameters. Along with circulating miRNAs, tissue miRNAs have shown promise as markers that can predict cancer recurrence and/or the potential for survival of cancer patients. Additionally, some miRNAs have therapeutic potential. In this review, we discuss and assess the usefulness of tissue-derived and circulating miRNAs for the diagnosis and prognosis of prostate cancer.
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spelling pubmed-38215232013-11-12 MicroRNAs in prostate cancer Kim, Won Tae Kim, Wun-Jae Prostate Int Review Article MicroRNAs (miRNAs) are made up of −22 endogenous nucleotides and are small, noncoding RNAs that are important regulators of gene expression at the posttranscriptional level by degrading or repressing target miRNAs. miRNA expression profiles can be used for the detection of diagnostic and prognostic markers for various cancers. Also, alterations of miRNAs in cancer tissues have been associated with clinicopathological parameters. Along with circulating miRNAs, tissue miRNAs have shown promise as markers that can predict cancer recurrence and/or the potential for survival of cancer patients. Additionally, some miRNAs have therapeutic potential. In this review, we discuss and assess the usefulness of tissue-derived and circulating miRNAs for the diagnosis and prognosis of prostate cancer. Asian Pacific Prostate Society (APPS) 2012-12-13 2013 /pmc/articles/PMC3821523/ /pubmed/24223395 http://dx.doi.org/10.12954/PI.12011 Text en © 2013 Asian Pacific Prostate Society (APPS) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Won Tae
Kim, Wun-Jae
MicroRNAs in prostate cancer
title MicroRNAs in prostate cancer
title_full MicroRNAs in prostate cancer
title_fullStr MicroRNAs in prostate cancer
title_full_unstemmed MicroRNAs in prostate cancer
title_short MicroRNAs in prostate cancer
title_sort micrornas in prostate cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821523/
https://www.ncbi.nlm.nih.gov/pubmed/24223395
http://dx.doi.org/10.12954/PI.12011
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