Cargando…
Keratin K15 as a Biomarker of Epidermal Stem Cells
Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821562/ https://www.ncbi.nlm.nih.gov/pubmed/24071939 http://dx.doi.org/10.3390/ijms141019385 |
_version_ | 1782290316341018624 |
---|---|
author | Bose, Amrita Teh, Muy-Teck Mackenzie, Ian C. Waseem, Ahmad |
author_facet | Bose, Amrita Teh, Muy-Teck Mackenzie, Ian C. Waseem, Ahmad |
author_sort | Bose, Amrita |
collection | PubMed |
description | Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in the bulge of hair follicles. Conversely, suprabasal expression of K15 has also been reported in both normal and diseased tissues, which is inconsistent with its role as a stem cell marker. Our recently published work has given evidence of the molecular pathways that seem to control the expression of K15 in undifferentiated and differentiated cells. In this article, we have critically reviewed the published work to establish the reliability of K15 as an epidermal stem cell marker. |
format | Online Article Text |
id | pubmed-3821562 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-38215622013-11-11 Keratin K15 as a Biomarker of Epidermal Stem Cells Bose, Amrita Teh, Muy-Teck Mackenzie, Ian C. Waseem, Ahmad Int J Mol Sci Review Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in the bulge of hair follicles. Conversely, suprabasal expression of K15 has also been reported in both normal and diseased tissues, which is inconsistent with its role as a stem cell marker. Our recently published work has given evidence of the molecular pathways that seem to control the expression of K15 in undifferentiated and differentiated cells. In this article, we have critically reviewed the published work to establish the reliability of K15 as an epidermal stem cell marker. Molecular Diversity Preservation International (MDPI) 2013-09-25 /pmc/articles/PMC3821562/ /pubmed/24071939 http://dx.doi.org/10.3390/ijms141019385 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Bose, Amrita Teh, Muy-Teck Mackenzie, Ian C. Waseem, Ahmad Keratin K15 as a Biomarker of Epidermal Stem Cells |
title | Keratin K15 as a Biomarker of Epidermal Stem Cells |
title_full | Keratin K15 as a Biomarker of Epidermal Stem Cells |
title_fullStr | Keratin K15 as a Biomarker of Epidermal Stem Cells |
title_full_unstemmed | Keratin K15 as a Biomarker of Epidermal Stem Cells |
title_short | Keratin K15 as a Biomarker of Epidermal Stem Cells |
title_sort | keratin k15 as a biomarker of epidermal stem cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821562/ https://www.ncbi.nlm.nih.gov/pubmed/24071939 http://dx.doi.org/10.3390/ijms141019385 |
work_keys_str_mv | AT boseamrita keratink15asabiomarkerofepidermalstemcells AT tehmuyteck keratink15asabiomarkerofepidermalstemcells AT mackenzieianc keratink15asabiomarkerofepidermalstemcells AT waseemahmad keratink15asabiomarkerofepidermalstemcells |