The COX-2 Selective Blocker Etodolac Inhibits TNFα-Induced Apoptosis in Isolated Rabbit Articular Chondrocytes

Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation of volume-sensitive Cl(−) current (I(Cl,vol)) mediates cell shrinkage, triggering apoptosis in rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is fre...

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Detalles Bibliográficos
Autores principales: Kumagai, Kousuke, Kubo, Mitsuhiko, Imai, Shinji, Toyoda, Futoshi, Maeda, Tsutomu, Okumura, Noriaki, Matsuura, Hiroshi, Matsusue, Yoshitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821581/
https://www.ncbi.nlm.nih.gov/pubmed/24084720
http://dx.doi.org/10.3390/ijms141019705

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