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Immunosenescence, Aging, and Systemic Lupus Erythematous

Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is...

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Detalles Bibliográficos
Autor principal: Montoya-Ortiz, Gladis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821895/
https://www.ncbi.nlm.nih.gov/pubmed/24260712
http://dx.doi.org/10.1155/2013/267078
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author Montoya-Ortiz, Gladis
author_facet Montoya-Ortiz, Gladis
author_sort Montoya-Ortiz, Gladis
collection PubMed
description Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.). These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity. This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients.
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spelling pubmed-38218952013-11-20 Immunosenescence, Aging, and Systemic Lupus Erythematous Montoya-Ortiz, Gladis Autoimmune Dis Review Article Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.). These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity. This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients. Hindawi Publishing Corporation 2013 2013-10-24 /pmc/articles/PMC3821895/ /pubmed/24260712 http://dx.doi.org/10.1155/2013/267078 Text en Copyright © 2013 Gladis Montoya-Ortiz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Montoya-Ortiz, Gladis
Immunosenescence, Aging, and Systemic Lupus Erythematous
title Immunosenescence, Aging, and Systemic Lupus Erythematous
title_full Immunosenescence, Aging, and Systemic Lupus Erythematous
title_fullStr Immunosenescence, Aging, and Systemic Lupus Erythematous
title_full_unstemmed Immunosenescence, Aging, and Systemic Lupus Erythematous
title_short Immunosenescence, Aging, and Systemic Lupus Erythematous
title_sort immunosenescence, aging, and systemic lupus erythematous
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821895/
https://www.ncbi.nlm.nih.gov/pubmed/24260712
http://dx.doi.org/10.1155/2013/267078
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