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Immunosenescence, Aging, and Systemic Lupus Erythematous
Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821895/ https://www.ncbi.nlm.nih.gov/pubmed/24260712 http://dx.doi.org/10.1155/2013/267078 |
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author | Montoya-Ortiz, Gladis |
author_facet | Montoya-Ortiz, Gladis |
author_sort | Montoya-Ortiz, Gladis |
collection | PubMed |
description | Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.). These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity. This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients. |
format | Online Article Text |
id | pubmed-3821895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38218952013-11-20 Immunosenescence, Aging, and Systemic Lupus Erythematous Montoya-Ortiz, Gladis Autoimmune Dis Review Article Senescence is a normal biological process that occurs in all organisms and involves a decline in cell functions. This process is caused by molecular regulatory machinery alterations, and it is closely related to telomere erosion in chromosomes. In the context of the immune system, this phenomenon is known as immunosenescence and refers to the immune function deregulation. Therefore, functions of several cells involved in the innate and adaptive immune responses are severely compromised with age progression (e.g., changes in lymphocyte subsets, decreased proliferative responses, chronic inflammatory states, etc.). These alterations make elderly individuals prone to not only infectious diseases but also to malignancy and autoimmunity. This review will explore the molecular aspects of processes related to cell aging, their importance in the context of the immune system, and their participation in elderly SLE patients. Hindawi Publishing Corporation 2013 2013-10-24 /pmc/articles/PMC3821895/ /pubmed/24260712 http://dx.doi.org/10.1155/2013/267078 Text en Copyright © 2013 Gladis Montoya-Ortiz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Montoya-Ortiz, Gladis Immunosenescence, Aging, and Systemic Lupus Erythematous |
title | Immunosenescence, Aging, and Systemic Lupus Erythematous |
title_full | Immunosenescence, Aging, and Systemic Lupus Erythematous |
title_fullStr | Immunosenescence, Aging, and Systemic Lupus Erythematous |
title_full_unstemmed | Immunosenescence, Aging, and Systemic Lupus Erythematous |
title_short | Immunosenescence, Aging, and Systemic Lupus Erythematous |
title_sort | immunosenescence, aging, and systemic lupus erythematous |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821895/ https://www.ncbi.nlm.nih.gov/pubmed/24260712 http://dx.doi.org/10.1155/2013/267078 |
work_keys_str_mv | AT montoyaortizgladis immunosenescenceagingandsystemiclupuserythematous |