Activation of transposable elements during aging and neuronal decline in Drosophila

We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shorten...

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Detalles Bibliográficos
Autores principales: Li, W., Prazak, L., Chatterjee, N., Grüninger, S, Krug, L., Theodorou, D., Dubnau, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821974/
https://www.ncbi.nlm.nih.gov/pubmed/23563579
http://dx.doi.org/10.1038/nn.3368
Descripción
Sumario:We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

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