Activation of transposable elements during aging and neuronal decline in Drosophila

We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shorten...

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Autores principales: Li, W., Prazak, L., Chatterjee, N., Grüninger, S, Krug, L., Theodorou, D., Dubnau, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821974/
https://www.ncbi.nlm.nih.gov/pubmed/23563579
http://dx.doi.org/10.1038/nn.3368
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author Li, W.
Prazak, L.
Chatterjee, N.
Grüninger, S
Krug, L.
Theodorou, D.
Dubnau, J.
author_facet Li, W.
Prazak, L.
Chatterjee, N.
Grüninger, S
Krug, L.
Theodorou, D.
Dubnau, J.
author_sort Li, W.
collection PubMed
description We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
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spelling pubmed-38219742013-11-10 Activation of transposable elements during aging and neuronal decline in Drosophila Li, W. Prazak, L. Chatterjee, N. Grüninger, S Krug, L. Theodorou, D. Dubnau, J. Nat Neurosci Article We report the surprising finding that several transposable elements are highly active in Drosophila brain during normal aging. We also show that mutations in Drosophila Argonaute 2 (dAgo2) exhibit exacerbated transposon expression in brain, progressive and age-dependent memory impairment and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function. 2013-04-07 2013-05 /pmc/articles/PMC3821974/ /pubmed/23563579 http://dx.doi.org/10.1038/nn.3368 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Li, W.
Prazak, L.
Chatterjee, N.
Grüninger, S
Krug, L.
Theodorou, D.
Dubnau, J.
Activation of transposable elements during aging and neuronal decline in Drosophila
title Activation of transposable elements during aging and neuronal decline in Drosophila
title_full Activation of transposable elements during aging and neuronal decline in Drosophila
title_fullStr Activation of transposable elements during aging and neuronal decline in Drosophila
title_full_unstemmed Activation of transposable elements during aging and neuronal decline in Drosophila
title_short Activation of transposable elements during aging and neuronal decline in Drosophila
title_sort activation of transposable elements during aging and neuronal decline in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821974/
https://www.ncbi.nlm.nih.gov/pubmed/23563579
http://dx.doi.org/10.1038/nn.3368
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